EC number:2.1.1.220

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.220
Description:tRNA (adenine(58)-N(1))-methyltransferase.
Alternative Name: tRNA m(1)A(58) methyltransferase.
tRNA (m(1)A(58)) methyltransferase.
Cath: 3.40.50.150; 3.10.330.20;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.220
BRENDA Enzyme Link: BRENDA 2.1.1.220
KEGG Enzyme Link: KEGG2.1.1.220
BioCyc Enzyme Link: BioCyc 2.1.1.220
ExPASy Enzyme Link: ExPASy2.1.1.220
EC2PDB Enzyme Link: EC2PDB 2.1.1.220
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.220
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.220
IntEnz Enzyme Link: IntEnz 2.1.1.220
MEDLINE Enzyme Link: MEDLINE 2.1.1.220

EC number:2.1.1.220

MSA:

2.1.1.220;
Phylogenetic Tree:

2.1.1.220;
Uniprot:
M-CSA:
RHEA:43152 adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[c;H0;+0:6](-[NH2;+0:7]):[n;H0;+0:8]:[*:9]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[c;H0;+0:6](=[NH;+0:7]):[n;H0;+0:8](:[*:9])-[CH3;+0:4]
Reaction
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References

TitleAuthorsDatePubMed ID
Crystallization and preliminary X-ray diffraction crystallographic study of tRNA m(1)A58 methyltransferase from Saccharomyces cerevisiae.Qiu X, Huang K, Ma J, Gao Y2011 Nov 122102254
Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase.Varshney U, Ramesh V, Madabushi A, Gaur R, Subramanya HS, RajBhandary UL200414960715
Cloning and characterization of tRNA (m1A58) methyltransferase (TrmI) from Thermus thermophilus HB27, a protein required for cell growth at extreme temperatures.Droogmans L, Roovers M, Bujnicki JM, Tricot C, Hartsch T, Stalon V, Grosjean H2003 Apr 1512682365
The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae.Anderson J, Phan L, Hinnebusch AG2000 May 910779558