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2. Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

ID:	2.1.1.337
Description:	Reticuline N-methyltransferase.

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UniProtKB Enzyme Link:	UniProtKB 2.1.1.337
BRENDA Enzyme Link:	BRENDA 2.1.1.337
KEGG Enzyme Link:	KEGG2.1.1.337
BioCyc Enzyme Link:	BioCyc 2.1.1.337
ExPASy Enzyme Link:	ExPASy2.1.1.337
EC2PDB Enzyme Link:	EC2PDB 2.1.1.337
ExplorEnz Enzyme Link:	ExplorEnz 2.1.1.337
PRIAM enzyme-specific profiles Link:	PRIAM 2.1.1.337
IntEnz Enzyme Link:	IntEnz 2.1.1.337
MEDLINE Enzyme Link:	MEDLINE 2.1.1.337

RHEA:51516	(R)-reticuline + S-adenosyl-L-methionine = (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[N;H0;+0:2](-[:3])-[:4].[:5]-[S+;H0:6](-[:7])-[CH3;+0:8]>>[:1]-[N+;H0:2](-[:3])(-[:4])-[CH3;+0:8].[:5]-[S;H0;+0:6]-[:7]
Reaction
Core-to-Core	More

Title	Authors	Date	PubMed ID
Isolation and Characterization of Reticuline N-Methyltransferase Involved in Biosynthesis of the Aporphine Alkaloid Magnoflorine in Opium Poppy.	Morris JS, Facchini PJ	2016 Nov 4	27634038

RHEA:51520	(S)-reticuline + S-adenosyl-L-methionine = (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[N;H0;+0:2](-[:3])-[:4].[:5]-[S+;H0:6](-[:7])-[CH3;+0:8]>>[:1]-[N+;H0:2](-[:3])(-[:4])-[CH3;+0:8].[:5]-[S;H0;+0:6]-[:7]
Reaction
Core-to-Core	More

Title	Authors	Date	PubMed ID
Isolation and Characterization of Reticuline N-Methyltransferase Involved in Biosynthesis of the Aporphine Alkaloid Magnoflorine in Opium Poppy.	Morris JS, Facchini PJ	2016 Nov 4	27634038
Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism.	Torres MA, Hoffarth E, Eugenio L, Savtchouk J, Chen X, Morris JS, Facchini PJ, Ng KK	2016 Nov 4	27573242

RHEA:51524	(S)-corytuberine + S-adenosyl-L-methionine = magnoflorine + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[N;H0;+0:2](-[:3])-[:4].[:5]-[S+;H0:6](-[:7])-[CH3;+0:8]>>[:1]-[N+;H0:2](-[:3])(-[:4])-[CH3;+0:8].[:5]-[S;H0;+0:6]-[:7]
Reaction
Core-to-Core	More

Title	Authors	Date	PubMed ID
Isolation and Characterization of Reticuline N-Methyltransferase Involved in Biosynthesis of the Aporphine Alkaloid Magnoflorine in Opium Poppy.	Morris JS, Facchini PJ	2016 Nov 4	27634038
Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism.	Torres MA, Hoffarth E, Eugenio L, Savtchouk J, Chen X, Morris JS, Facchini PJ, Ng KK	2016 Nov 4	27573242

RHEA:51548	(R)-tetrahydropapaverine + S-adenosyl-L-methionine = (R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[NH;+0:2]-[:3].[:4]-[S+;H0:5](-[:6])-[CH3;+0:7]>>[:1]-[N;H0;+0:2](-[:3])-[CH3;+0:7].[:4]-[S;H0;+0:5]-[:6]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism.	Torres MA, Hoffarth E, Eugenio L, Savtchouk J, Chen X, Morris JS, Facchini PJ, Ng KK	2016 Nov 4	27573242

RHEA:51556	(S)-glaucine + S-adenosyl-L-methionine = (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[N;H0;+0:2](-[:3])-[:4].[:5]-[S+;H0:6](-[:7])-[CH3;+0:8]>>[:1]-[N+;H0:2](-[:3])(-[:4])-[CH3;+0:8].[:5]-[S;H0;+0:6]-[:7]
Reaction
Core-to-Core	More

Title	Authors	Date	PubMed ID
Isolation and Characterization of Reticuline N-Methyltransferase Involved in Biosynthesis of the Aporphine Alkaloid Magnoflorine in Opium Poppy.	Morris JS, Facchini PJ	2016 Nov 4	27634038

RHEA:51560	(S)-bulbocapnine + S-adenosyl-L-methionine = (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1)	[:1]-[N;H0;+0:2](-[:3])-[:4].[:5]-[S+;H0:6](-[:7])-[CH3;+0:8]>>[:1]-[N+;H0:2](-[:3])(-[:4])-[CH3;+0:8].[:5]-[S;H0;+0:6]-[:7]
Reaction
Core-to-Core	More

Title	Authors	Date	PubMed ID
Isolation and Characterization of Reticuline N-Methyltransferase Involved in Biosynthesis of the Aporphine Alkaloid Magnoflorine in Opium Poppy.	Morris JS, Facchini PJ	2016 Nov 4	27634038