EC number:2.1.1.63
| ID: | 2.1.1.63 |
|---|---|
| Description: | Methylated-DNA--[protein]-cysteine S-methyltransferase. |
| Alternative Name: |
O-6-methylguanine-DNA-alkyltransferase. 6-O-methylguanine-DNA methyltransferase. |
| Prosite: | PDOC00320; |
| PDB: |
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| Cath: | 1.10.10.10; 1.10.10.60; 3.30.160.460; 3.30.160.70; 3.40.10.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.63 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.63 |
| KEGG Enzyme Link: | KEGG2.1.1.63 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.63 |
| ExPASy Enzyme Link: | ExPASy2.1.1.63 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.63 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.63 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.63 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.63 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.63 |
| RHEA:53428 | a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein] |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]:[c;H0;+0:4](-[O;H0;+0:5]-[CH3;+0:6]):[n;H0;+0:7]:[*:8]>>[*:1]-[S;H0;+0:2]-[CH3;+0:6].[*:3]:[c;H0;+0:4](=[O;H0;+0:5]):[nH;+0:7]:[*:8] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli. | Foote RS, Mitra S, Pal BC | 1980 Nov 28 | 7008792 |
| Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue. | Olsson M, Lindahl T | 1980 Nov 25 | 7000780 |
| Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coli. | McCarthy TV, Lindahl T | 1985 Apr 25 | 2987862 |
| Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli. | Potter PM, Wilkinson MC, Fitton J, Carr FJ, Brennand J, Cooper DP, Margison GP | 1987 Nov 25 | 2825131 |
| Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium. | Rebeck GW, Smith CM, Goad DL, Samson L | 1989 Sep | 2670886 |
| Purification, structure, and biochemical properties of human O6-methylguanine-DNA methyltransferase. | Koike G, Maki H, Takeya H, Hayakawa H, Sekiguchi M | 1990 Sep 5 | 2394694 |
| Primary sequence and biological functions of a Saccharomyces cerevisiae O6-methylguanine/O4-methylthymine DNA repair methyltransferase gene. | Xiao W, Derfler B, Chen J, Samson L | 1991 Aug | 2065659 |
| Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases. | Sassanfar M, Dosanjh MK, Essigmann JM, Samson L | 1991 Feb 15 | 1993655 |
| Repair of DNA containing O6-alkylguanine. | Pegg AE, Byers TL | 1992 Mar | 1544541 |
| RHEA:24000 | a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein] |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]:[c;H0;+0:4](-[O;H0;+0:5]-[CH3;+0:6]):[n;H0;+0:7]:[*:8]>>[*:1]-[S;H0;+0:2]-[CH3;+0:6].[*:3]:[c;H0;+0:4](=[O;H0;+0:5]):[nH;+0:7]:[*:8] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli. | Foote RS, Mitra S, Pal BC | 1980 Nov 28 | 7008792 |
| Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue. | Olsson M, Lindahl T | 1980 Nov 25 | 7000780 |
| Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coli. | McCarthy TV, Lindahl T | 1985 Apr 25 | 2987862 |
| Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli. | Potter PM, Wilkinson MC, Fitton J, Carr FJ, Brennand J, Cooper DP, Margison GP | 1987 Nov 25 | 2825131 |
| Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium. | Rebeck GW, Smith CM, Goad DL, Samson L | 1989 Sep | 2670886 |
| Purification, structure, and biochemical properties of human O6-methylguanine-DNA methyltransferase. | Koike G, Maki H, Takeya H, Hayakawa H, Sekiguchi M | 1990 Sep 5 | 2394694 |
| Primary sequence and biological functions of a Saccharomyces cerevisiae O6-methylguanine/O4-methylthymine DNA repair methyltransferase gene. | Xiao W, Derfler B, Chen J, Samson L | 1991 Aug | 2065659 |
| Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases. | Sassanfar M, Dosanjh MK, Essigmann JM, Samson L | 1991 Feb 15 | 1993655 |
| Repair of DNA containing O6-alkylguanine. | Pegg AE, Byers TL | 1992 Mar | 1544541 |