EC number:2.1.1.74

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.74
Description:(FADH(2)-oxidizing).
Alternative Name: Folate/FAD-dependent tRNA T54 methyltransferase.
Folate-dependent ribothymidyl synthase.
Cath: 3.40.1350.30; 3.50.50.60; 2.40.50.140; 3.40.50.150;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.74
BRENDA Enzyme Link: BRENDA 2.1.1.74
KEGG Enzyme Link: KEGG2.1.1.74
BioCyc Enzyme Link: BioCyc 2.1.1.74
ExPASy Enzyme Link: ExPASy2.1.1.74
EC2PDB Enzyme Link: EC2PDB 2.1.1.74
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.74
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.74
IntEnz Enzyme Link: IntEnz 2.1.1.74
MEDLINE Enzyme Link: MEDLINE 2.1.1.74

EC number:2.1.1.74

MSA:

2.1.1.74;
Phylogenetic Tree:

2.1.1.74;
Uniprot:
M-CSA:
RHEA:16873 (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + FADH2 + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + FAD + H(+)
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[*:3]-[*:4]-[N;H0;+0:5](-[*:6])-[CH2;+0:7]-1.[*:8]:[cH;+0:9]:[*:10]>>[*:1]-[NH;+0:2]-[*:3]-[*:4]-[NH;+0:5]-[*:6].[*:8]:[c;H0;+0:9](:[*:10])-[CH3;+0:7]
Reaction
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References

TitleAuthorsDatePubMed ID
Major identity determinants for enzymatic formation of ribothymidine and pseudouridine in the T psi-loop of yeast tRNAs.Becker HF, Motorin Y, Sissler M, Florentz C, Grosjean H1997 Dec 129417931
Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase.Nishimasu H, Ishitani R, Yamashita K, Iwashita C, Hirata A, Hori H, Nureki O2009 May 1919416846