EC number:2.1.2.8

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.2 Hydroxymethyl-, formyl- and related transferases
ID:2.1.2.8
Description:Deoxycytidylate 5-hydroxymethyltransferase.
Alternative Name: Deoxycytidylate hydroxymethyltransferase.
Deoxycytidylate hydroxymethylase.
dCMP hydroxymethylase.
Cath: 3.30.572.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.2.8
BRENDA Enzyme Link: BRENDA 2.1.2.8
KEGG Enzyme Link: KEGG2.1.2.8
BioCyc Enzyme Link: BioCyc 2.1.2.8
ExPASy Enzyme Link: ExPASy2.1.2.8
EC2PDB Enzyme Link: EC2PDB 2.1.2.8
ExplorEnz Enzyme Link: ExplorEnz 2.1.2.8
PRIAM enzyme-specific profiles Link: PRIAM 2.1.2.8
IntEnz Enzyme Link: IntEnz 2.1.2.8
MEDLINE Enzyme Link: MEDLINE 2.1.2.8

EC number:2.1.2.8

MSA:

2.1.2.8;
Phylogenetic Tree:

2.1.2.8;
Uniprot:
M-CSA:
RHEA:11280 (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[*:3]-[*:4]-[N;H0;+0:5](-[*:6])-[CH2;+0:7]-1.[*:8]:[cH;+0:9]:[*:10].[OH2;+0:11]>>[*:1]-[NH;+0:2]-[*:3]-[*:4]-[NH;+0:5]-[*:6].[*:8]:[c;H0;+0:9](:[*:10])-[CH2;+0:7]-[OH;+0:11]
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References

TitleAuthorsDatePubMed ID
Deoxycytidylate hydroxymethylase gene of bacteriophage T4. Nucleotide sequence determination and over-expression of the gene.Lamm N, Wang Y, Mathews CK, Rüger W1988 Mar 153350013
VIRUS-INDUCED ACQUISITION OF METABOLIC FUNCTION. VII. BIOSYNTHESIS DE NOVO OF DEOXYCYTIDYLATE HYDROXYMETHYLASE.MATHEWS CK, BROWN F, COHEN SS1964 Sep14217882
Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex.Song HK, Sohn SH, Suh SW1999 Mar 110064578