EC number:2.3.1.161
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.161 | ||
|---|---|---|---|
| Description: | Lovastatin nonaketide synthase. | ||
| Prosite: | PDOC00529; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.161 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.161 |
| KEGG Enzyme Link: | KEGG2.3.1.161 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.161 |
| ExPASy Enzyme Link: | ExPASy2.3.1.161 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.161 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.161 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.161 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.161 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.161 |
EC number:2.3.1.161
| MSA: | |
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| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:18565 | 19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine = 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Complete reconstitution of a highly reducing iterative polyketide synthase. | Ma SM, Li JW, Choi JW, Zhou H, Lee KK, Moorthie VA, Xie X, Kealey JT, Da Silva NA, Vederas JC, Tang Y | 2009 Oct 23 | 19900898 |
| Lovastatin biosynthesis in Aspergillus terreus: characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene. | Hendrickson L, Davis CR, Roach C, Nguyen DK, Aldrich T, McAda PC, Reeves CD | 1999 Jul | 10381407 |
| Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. | Kennedy J, Auclair K, Kendrew SG, Park C, Vederas JC, Hutchinson CR | 1999 May 21 | 10334994 |
| LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. | Xu W, Chooi YH, Choi JW, Li S, Vederas JC, Da Silva NA, Tang Y | 2013 Jun 17 | 23653178 |