EC number:2.3.1.176
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.176 | ||
|---|---|---|---|
| Description: | Propanoyl-CoA C-acyltransferase. | ||
| Alternative Name: |
Sterol carrier protein-X. Sterol carrier protein-chi. SCP-X. SCP(chi). PTE-2. Propionyl-CoA C(2)-trimethyltridecanoyltransferase. Peroxisomal thiolase 2. 3-oxopristanoyl-CoA thiolase. 3-oxopristanoyl-CoA hydrolase. | ||
| Prosite: | PDOC00092; | ||
| PDB: |
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| Cath: | 3.30.1050.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.176 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.176 |
| KEGG Enzyme Link: | KEGG2.3.1.176 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.176 |
| ExPASy Enzyme Link: | ExPASy2.3.1.176 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.176 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.176 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.176 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.176 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.176 |
EC number:2.3.1.176
| MSA: | |
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| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:16865 | choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[*:6])-[S;H0;+0:7]-[*:8]>>[*:1]-[CH;+0:2](-[*:3])-[C;H0;+0:5](=[*:4])-[*:6].[*:8]-[SH;+0:7] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Substrate specificities of 3-oxoacyl-CoA thiolase A and sterol carrier protein 2/3-oxoacyl-CoA thiolase purified from normal rat liver peroxisomes. Sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in the metabolism of 2-methyl-branched fatty acids and bile acid intermediates. | Antonenkov VD, Van Veldhoven PP, Waelkens E, Mannaerts GP | 1997 Oct 10 | 9325339 |
| A second isoform of 3-ketoacyl-CoA thiolase found in Caenorhabditis elegans, which is similar to sterol carrier protein x but lacks the sequence of sterol carrier protein 2. | Bun-Ya M, Maebuchi M, Hashimoto T, Yokota S, Kamiryo T | 1997 Apr 15 | 9151950 |
| Conversion of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid into cholic acid by rat liver peroxisomes. | Pedersen JI, Gustafsson J | 1980 Dec 1 | 7461136 |
| Formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes. | Kase F, Björkhem I, Pedersen JI | 1983 Dec | 6668450 |
| Peroxisomal fatty acid oxidation disorders and 58 kDa sterol carrier protein X (SCPx). Activity measurements in liver and fibroblasts using a newly developed method. | Ferdinandusse S, Denis S, van Berkel E, Dacremont G, Wanders RJ | 2000 Mar | 10706581 |
| Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. | Falany CN, Johnson MR, Barnes S, Diasio RB | 1994 Jul 29 | 8034703 |
| The enzymes, regulation, and genetics of bile acid synthesis. | Russell DW | 2003 | 12543708 |
| RHEA:10408 | 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[*:6])-[S;H0;+0:7]-[*:8]>>[*:1]-[CH;+0:2](-[*:3])-[C;H0;+0:5](=[*:4])-[*:6].[*:8]-[SH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes. | Wanders RJ, Denis S, Wouters F, Wirtz KW, Seedorf U | 1997 Jul 30 | 9245689 |