EC number:2.3.1.244
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.244 |
|---|---|
| Description: | 2-methylbutanoate polyketide synthase. |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.244 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.244 |
| KEGG Enzyme Link: | KEGG2.3.1.244 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.244 |
| ExPASy Enzyme Link: | ExPASy2.3.1.244 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.244 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.244 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.244 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.244 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.244 |
EC number:2.3.1.244
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:42852 | 3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[CH;+0:3]-[N;H0;+0:4](-[*:5])-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-1.[*:9]-[C;H0;+0:10]1=[CH;+0:11]-[N;H0;+0:12](-[*:13])-[CH;+0:14]=[CH;+0:15]-[CH2;+0:16]-1.[*:17]-[S+;H0:18](-[*:19])-[CH3;+0:20].[*:21]-[S;H0;+0:22]-[C;H0;+0:23](=[O;H0;+0:24])-[CH2;+0:25]-[C;H0;+0:26](=[O;H0;+0:27])-[OH;+0:28].[*:29]-[SH;+0:30].[*:31]=[C;H0;+0:32](-[OH;+0:33])-[CH2;+0:34]-[C;H0;+0:35](=[*:36])-[S;H0;+0:37]-[*:38].[H+;H0:39].[H+;H0:40].[H+;H0:41]>>[*:17]-[S;H0;+0:18]-[*:19].[*:29]-[S;H0;+0:30]-[C;H0;+0:35](=[*:36])-[CH;+0:34](-[CH3;+0:26])-[CH2;+0:25]-[CH3;+0:23].[*:38]-[SH;+0:37].[*:21]-[SH;+0:22].[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[n+;H0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]-[c;H0;+0:10]1:[cH;+0:11]:[n+;H0:12](-[*:13]):[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:1.[*:31]=[C;H0;+0:32]=[O;H0;+0:33].[O;H0;+0:27]=[C;H0;+0:20]=[O;H0;+0:24].[OH2;+0:28] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. | Kennedy J, Auclair K, Kendrew SG, Park C, Vederas JC, Hutchinson CR | 1999 May 21 | 10334994 |
| FT-ICR-MS characterization of intermediates in the biosynthesis of the α-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF. | Meehan MJ, Xie X, Zhao X, Xu W, Tang Y, Dorrestein PC | 2011 Jan 18 | 21069965 |
| Identification of mokB involved in monacolin K biosynthesis in Monascus pilosus. | Sakai K, Kinoshita H, Nihira T | 2009 Dec | 19693441 |
| Acyltransferase mediated polyketide release from a fungal megasynthase. | Xie X, Meehan MJ, Xu W, Dorrestein PC, Tang Y | 2009 Jun 24 | 19530726 |