EC number:2.3.2.6
| ID: | 2.3.2.6 |
|---|---|
| Description: | Lysine/arginine leucyltransferase. |
| Alternative Name: |
Leucyltransferase. Leucyl/phenylalanyl-tRNA--protein transferase. Leucyl-tRNA--protein transferase. L/F transferase. |
| Cath: | 3.40.630.70; 2.30.210.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.2.6 |
| BRENDA Enzyme Link: | BRENDA 2.3.2.6 |
| KEGG Enzyme Link: | KEGG2.3.2.6 |
| BioCyc Enzyme Link: | BioCyc 2.3.2.6 |
| ExPASy Enzyme Link: | ExPASy2.3.2.6 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.2.6 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.2.6 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.2.6 |
| IntEnz Enzyme Link: | IntEnz 2.3.2.6 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.2.6 |
| RHEA:50416 | L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu) |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[O;H0;+0:4]-[C;H0;+0:5](=[*:6])-[*:7]>>[*:3]-[OH;+0:4].[*:6]=[C;H0;+0:5](-[*:7])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The N-end rule in Escherichia coli: cloning and analysis of the leucyl, phenylalanyl-tRNA-protein transferase gene aat. | Shrader TE, Tobias JW, Varshavsky A | 1993 Jul | 8331068 |
| The leucyl/phenylalanyl-tRNA-protein transferase. Overexpression and characterization of substrate recognition, domain structure, and secondary structure. | Abramochkin G, Shrader TE | 1995 Sep 1 | 7657641 |
| Enzymatic modification of proteins. 3. Purification and properties of a leucyl, phenylalanyl transfer ribonucleic acid protein transferase from Escherichia coli. | Leibowitz MJ, Soffer RL | 1970 Apr 25 | 4909560 |
| A soluble enzyme from Escherichia coli which catalyzes the transfer of leucine and phenylalanine from tRNA to acceptor proteins. | Leibowitz MJ, Soffer RL | 1969 Jul 7 | 4894363 |
| Peptide acceptors in the leucine, phenylalanine transfer reaction. | Soffer RL | 1973 Dec 25 | 4587124 |
| The N-end rule in bacteria. | Tobias JW, Shrader TE, Rocap G, Varshavsky A | 1991 Nov 29 | 1962196 |
| RHEA:43632 | a [protein] N-terminus + L-phenylalanyl-tRNA(Phe) = N-terminal L-phenylalanyl-[protein] + tRNA(Phe) |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[O;H0;+0:4]-[C;H0;+0:5](=[*:6])-[*:7]>>[*:3]-[OH;+0:4].[*:6]=[C;H0;+0:5](-[*:7])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymatic modification of proteins. 3. Purification and properties of a leucyl, phenylalanyl transfer ribonucleic acid protein transferase from Escherichia coli. | Leibowitz MJ, Soffer RL | 1970 Apr 25 | 4909560 |
| A soluble enzyme from Escherichia coli which catalyzes the transfer of leucine and phenylalanine from tRNA to acceptor proteins. | Leibowitz MJ, Soffer RL | 1969 Jul 7 | 4894363 |
| Peptide acceptors in the leucine, phenylalanine transfer reaction. | Soffer RL | 1973 Dec 25 | 4587124 |
| RHEA:12340 | L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu) |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[O;H0;+0:4]-[C;H0;+0:5](=[*:6])-[*:7]>>[*:3]-[OH;+0:4].[*:6]=[C;H0;+0:5](-[*:7])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The N-end rule in Escherichia coli: cloning and analysis of the leucyl, phenylalanyl-tRNA-protein transferase gene aat. | Shrader TE, Tobias JW, Varshavsky A | 1993 Jul | 8331068 |
| The leucyl/phenylalanyl-tRNA-protein transferase. Overexpression and characterization of substrate recognition, domain structure, and secondary structure. | Abramochkin G, Shrader TE | 1995 Sep 1 | 7657641 |
| Enzymatic modification of proteins. 3. Purification and properties of a leucyl, phenylalanyl transfer ribonucleic acid protein transferase from Escherichia coli. | Leibowitz MJ, Soffer RL | 1970 Apr 25 | 4909560 |
| A soluble enzyme from Escherichia coli which catalyzes the transfer of leucine and phenylalanine from tRNA to acceptor proteins. | Leibowitz MJ, Soffer RL | 1969 Jul 7 | 4894363 |
| Peptide acceptors in the leucine, phenylalanine transfer reaction. | Soffer RL | 1973 Dec 25 | 4587124 |
| The N-end rule in bacteria. | Tobias JW, Shrader TE, Rocap G, Varshavsky A | 1991 Nov 29 | 1962196 |