EC number:2.4.1.135
| ID: | 2.4.1.135 |
|---|---|
| Description: | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase. |
| Alternative Name: |
Uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase. Glucuronosyltransferase I. |
| Cath: | 3.90.550.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.135 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.135 |
| KEGG Enzyme Link: | KEGG2.4.1.135 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.135 |
| ExPASy Enzyme Link: | ExPASy2.4.1.135 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.135 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.135 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.135 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.135 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.135 |
EC number:2.4.1.135
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:56508 | 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[*:6]-[OH;+0:7]>>[*:6]-[O;H0;+0:7]-[CH;+0:2](-[*:1])-[*:3].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| 2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis. | Tone Y, Pedersen LC, Yamamoto T, Izumikawa T, Kitagawa H, Nishihara J, Tamura J, Negishi M, Sugahara K | 2008 Jun 13 | 18400750 |
| RHEA:24168 | 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[*:6]-[OH;+0:7]>>[*:6]-[O;H0;+0:7]-[CH;+0:2](-[*:1])-[*:3].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans. | Kitagawa H, Tone Y, Tamura J, Neumann KW, Ogawa T, Oka S, Kawasaki T, Sugahara K | 1998 Mar 20 | 9506957 |
| Biosynthesis of chondroitin sulfate. II. Glucuronosyl transfer in the formation of the carbohydrate-protein linkage region. | Helting T, Rodén L | 1969 May 25 | 5770003 |
| Biosynthesis of heparin. Solubilization and partial purification of uridine diphosphate glucuronic acid: acceptor glucuronosyltransferase from mouse mastocytoma. | Helting T | 1972 Jul 10 | 4260846 |