EC number:2.4.1.152
| ID: | 2.4.1.152 |
|---|---|
| Description: | 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase. |
| Alternative Name: |
Plasma alpha-3-fucosyltransferase. Lewis-negative alpha-3-fucosyltransferase. Guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase. fucosyltransferase. GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L- Galactoside 3-fucosyltransferase. |
| Cath: | 3.40.50.11650; 3.40.50.11660; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.152 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.152 |
| KEGG Enzyme Link: | KEGG2.4.1.152 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.152 |
| ExPASy Enzyme Link: | ExPASy2.4.1.152 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.152 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.152 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.152 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.152 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.152 |
EC number:2.4.1.152
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:14257 | a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and heterologous expression of an alpha1,3-fucosyltransferase gene from the gastric pathogen Helicobacter pylori. | Ge Z, Chan NW, Palcic MM, Taylor DE | 1997 Aug 22 | 9261149 |
| Human salivary fucosyltransferases : evidence for two distinct alpha-3-L-fucosyltransferase activities one or which is associated with the Lewis blood group Le gene. | Johnson PH, Yates AD, Watkins WM | 1981 Jun | 7295318 |
| Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type. | Schachter H, Narasimhan S, Gleeson P, Vella G | 1983 | 6366476 |
| Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design. | Sun HY, Lin SW, Ko TP, Pan JF, Liu CL, Lin CN, Wang AH, Lin CH | 2007 Mar 30 | 17251184 |
| Carboxyl terminus of Helicobacter pylori alpha1,3-fucosyltransferase determines the structure and stability. | Lin SW, Yuan TM, Li JR, Lin CH | 2006 Jul 4 | 16800635 |
| A single aromatic amino acid at the carboxyl terminus of Helicobacter pylori {alpha}1,3/4 fucosyltransferase determines substrate specificity. | Ma B, Lau LH, Palcic MM, Hazes B, Taylor DE | 2005 Nov 4 | 16150700 |
| C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer. | Ma B, Wang G, Palcic MM, Hazes B, Taylor DE | 2003 Jun 13 | 12676935 |