EC number:2.4.1.17
| ID: | 2.4.1.17 |
|---|---|
| Description: | Glucuronosyltransferase. |
| Alternative Name: |
Uridine diphosphoglucuronyltransferase. Uridine diphosphoglucuronosyltransferase. Uridine diphosphoglucuronate-estriol glucuronosyltransferase. Uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase. Uridine diphosphoglucuronate-estradiol glucuronosyltransferase. Uridine diphosphoglucuronate-bilirubin glucuronosyltransferase. glucuronosyltransferase. Uridine diphosphoglucuronate-bilirubin glucuronoside Uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase. Uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase. Uridine diphosphate glucuronyltransferase. Uridine 5'-diphosphoglucuronyltransferase. UDPGT. UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific). UDPGA-glucuronyltransferase. UDPGA transferase. UDP-glucuronyltransferase. UDP-glucuronosyltransferase. UDP-glucuronate-bilirubin glucuronyltransferase. UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase. UDP glucuronyltransferase. UDP glucuronic acid transferase. UDP glucuronate-estriol glucuronosyltransferase. UDP glucuronate-estradiol-glucuronosyltransferase. PNP-UDPGT. Phenyl-UDP-glucuronosyltransferase. p-phenylphenol glucuronyltransferase. p-nitrophenylglucuronosyltransferase. p-nitrophenol UDP-glucuronyltransferase. p-nitrophenol UDP-glucuronosyltransferase. p-hydroxybiphenyl UDP glucuronyltransferase. Morphine glucuronyltransferase. GT. Estrone UDPglucuronosyltransferase. Estriol UDPglucuronosyltransferase. Ciramadol UDP-glucuronyltransferase. Bilirubin uridine diphosphoglucuronyltransferase. Bilirubin UDPGT. Bilirubin UDP-glucuronosyltransferase. Bilirubin monoglucuronide glucuronyltransferase. Bilirubin glucuronyltransferase. 4-nitrophenol UDPGT. 4-nitrophenol UDP-glucuronyltransferase. 4-methylumbelliferone UDP-glucuronosyltransferase. 4-hydroxybiphenyl UDP-glucuronosyltransferase. 3-OH androgenic UDPGT. 3-alpha-hydroxysteroid UDP-glucuronosyltransferase. 17-OH steroid UDPGT. 17-beta-hydroxysteroid UDP-glucuronosyltransferase. 1-naphthol-UDP-glucuronosyltransferase. 1-naphthol glucuronyltransferase. |
| Prosite: | PDOC00359; |
| PDB: |
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| Cath: | 3.40.50.20; 3.40.50.200; 3.40.50.2000; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.17 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.17 |
| KEGG Enzyme Link: | KEGG2.4.1.17 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.17 |
| ExPASy Enzyme Link: | ExPASy2.4.1.17 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.17 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.17 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.17 |
| RHEA:21032 | glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[*H;+0:6]>>[*:5]-[OH;+0:4].[*:1]-[CH;+0:2](-[*:3])-[*;H0;+0:6] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions. | Bock KW, Burchell B, Dutton GJ, Hänninen O, Mulder GJ, Owens IS, Siest G, Tephly TR | 1983 Mar 15 | 6404284 |
| Strain differences in purified rat hepatic 3 alpha-hydroxysteroid UDP-glucuronosyltransferase. | Green MD, Falany CN, Kirkpatrick RB, Tephly TR | 1985 Sep 1 | 3931633 |
| Identification of a sphingolipid α-glucuronosyltransferase that is essential for pollen function in Arabidopsis. | Rennie EA, Ebert B, Miles GP, Cahoon RE, Christiansen KM, Stonebloom S, Khatab H, Twell D, Petzold CJ, Adams PD, Dupree P, Heazlewood JL, Cahoon EB, Scheller HV | 2014 Aug | 25122154 |
| Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro. | Bellemare J, Rouleau M, Girard H, Harvey M, Guillemette C | 2010 Oct | 20610558 |
| Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity. | Girard H, Lévesque E, Bellemare J, Journault K, Caillier B, Guillemette C | 2007 Dec | 18004212 |
| Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substrates. | Udomuksorn W, Elliot DJ, Lewis BC, Mackenzie PI, Yoovathaworn K, Miners JO | 2007 Dec | 18004206 |
| Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7. | Miley MJ, Zielinska AK, Keenan JE, Bratton SM, Radominska-Pandya A, Redinbo MR | 2007 Jun 1 | 17442341 |
| Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase. | Lévesque E, Turgeon D, Carrier JS, Montminy V, Beaulieu M, Bélanger A | 2001 Apr 3 | 11300766 |
| Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital. | Bock KW, Josting D, Lilienblum W, Pfeil H | 1979 Jul | 111930 |