EC number:2.4.1.174
| ID: | 2.4.1.174 |
|---|---|
| Description: | acetylgalactosaminyltransferase. |
| Alternative Name: |
acetylgalactosaminyltransferase I. Uridine diphosphoacetylgalactosamine-chondroitin N-acetylgalactosaminyltransferase I. acetylgalactosaminyltransferase. Glucuronylgalactosylproteoglycan beta-1,4-N- |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.174 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.174 |
| KEGG Enzyme Link: | KEGG2.4.1.174 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.174 |
| ExPASy Enzyme Link: | ExPASy2.4.1.174 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.174 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.174 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.174 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.174 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.174 |
EC number:2.4.1.174
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:23464 | 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:6]-[O;H0;+0:7]-[CH;+0:3](-[*:4])-[*:5].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate. | Rohrmann K, Niemann R, Buddecke E | 1985 May 2 | 3922754 |
| Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans. | Mizuguchi S, Uyama T, Kitagawa H, Nomura KH, Dejima K, Gengyo-Ando K, Mitani S, Sugahara K, Nomura K | 2003 May 22 | 12761550 |
| Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis. | Hwang HY, Olson SK, Esko JD, Horvitz HR | 2003 May 22 | 12761549 |
| Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate. | Uyama T, Kitagawa H, Tamura Ji J, Sugahara K | 2002 Mar 15 | 11788602 |