EC number:2.4.1.175

Enzyme

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     2. Transferases
        2.4 Glycosyltransferases
            2.4.1 Hexosyltransferases
ID:2.4.1.175
Description:acetylgalactosaminyltransferase.
Alternative Name: acetylgalactosaminyltransferase II.
Uridine diphosphoacetylgalactosamine-chondroitin
galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase.
UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-
N-acetylgalactosaminyltransferase II.
acetylgalactosaminyltransferase.
Glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-
Chondroitin synthase.
Cath: 3.90.550.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.4.1.175
BRENDA Enzyme Link: BRENDA 2.4.1.175
KEGG Enzyme Link: KEGG2.4.1.175
BioCyc Enzyme Link: BioCyc 2.4.1.175
ExPASy Enzyme Link: ExPASy2.4.1.175
EC2PDB Enzyme Link: EC2PDB 2.4.1.175
ExplorEnz Enzyme Link: ExplorEnz 2.4.1.175
PRIAM enzyme-specific profiles Link: PRIAM 2.4.1.175
IntEnz Enzyme Link: IntEnz 2.4.1.175
MEDLINE Enzyme Link: MEDLINE 2.4.1.175

EC number:2.4.1.175

MSA:

2.4.1.175;
Phylogenetic Tree:

2.4.1.175;
Uniprot:
M-CSA:
RHEA:55000 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2]
Reaction
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Core-to-Core More
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References

TitleAuthorsDatePubMed ID
Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate.Rohrmann K, Niemann R, Buddecke E1985 May 23922754
Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4.Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K2002 Jun 1411943778
Molecular cloning and expression of a human chondroitin synthase.Kitagawa H, Uyama T, Sugahara K2001 Oct 1911514575
Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F.DeAngelis PL, Padgett-McCue AJ2000 Aug 410818104
RHEA:20800 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[*:6]-[OH;+0:7]>>[*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:7]-[*:6].[*:5]-[OH;+0:4]
Reaction
Core-to-Core More
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate.Rohrmann K, Niemann R, Buddecke E1985 May 23922754
Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4.Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K2002 Jun 1411943778
Molecular cloning and expression of a human chondroitin synthase.Kitagawa H, Uyama T, Sugahara K2001 Oct 1911514575
Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F.DeAngelis PL, Padgett-McCue AJ2000 Aug 410818104