EC number:2.4.1.186

Enzyme

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     2. Transferases
        2.4 Glycosyltransferases
            2.4.1 Hexosyltransferases
ID:2.4.1.186
Description:Glycogenin glucosyltransferase.
Alternative Name: Priming glucosyltransferase.
Glycogenin.
Cath: 1.20.20.30; 3.90.550.10; 3.40.50.20; 3.40.50.200; 3.40.50.2000;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.4.1.186
BRENDA Enzyme Link: BRENDA 2.4.1.186
KEGG Enzyme Link: KEGG2.4.1.186
BioCyc Enzyme Link: BioCyc 2.4.1.186
ExPASy Enzyme Link: ExPASy2.4.1.186
EC2PDB Enzyme Link: EC2PDB 2.4.1.186
ExplorEnz Enzyme Link: ExplorEnz 2.4.1.186
PRIAM enzyme-specific profiles Link: PRIAM 2.4.1.186
IntEnz Enzyme Link: IntEnz 2.4.1.186
MEDLINE Enzyme Link: MEDLINE 2.4.1.186

EC number:2.4.1.186

MSA:

2.4.1.186;
Phylogenetic Tree:

2.4.1.186;
Uniprot:
M-CSA:
RHEA:56560 [1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2]
Reaction
Core-to-Core More
Core-to-Core More
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References

TitleAuthorsDatePubMed ID
Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle.Pitcher J, Smythe C, Cohen P1988 Sep 152970965
Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism.Mu J, Roach PJ1998 Dec 259857012
A precursor of glycogen biosynthesis: alpha-1,4-glucan-protein.Krisman CR, Barengo R1975 Mar 3809265
Catalytic activities of glycogenin additional to autocatalytic self-glucosylation.Alonso MD, Lomako J, Lomako WM, Whelan WJ1995 Jun 237797519
A new look at the biogenesis of glycogen.Alonso MD, Lomako J, Lomako WM, Whelan WJ1995 Sep7672505
A novel glycosyl-amino acid linkage: rabbit-muscle glycogen is covalently linked to a protein via tyrosine.Rodriguez IR, Whelan WJ1985 Oct 304062948
Identification of the 38-kDa subunit of rabbit skeletal muscle glycogen synthase as glycogenin.Pitcher J, Smythe C, Campbell DG, Cohen P1987 Dec 153121316
A self-glucosylating protein is the primer for rabbit muscle glycogen biosynthesis.Lomako J, Lomako WM, Whelan WJ1988 Dec2973423
Structural basis for the recruitment of glycogen synthase by glycogenin.Zeqiraj E, Tang X, Hunter RW, García-Rocha M, Judd A, Deak M, von Wilamowitz-Moellendorff A, Kurinov I, Guinovart JJ, Tyers M, Sakamoto K, Sicheri F2014 Jul 1524982189
Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin.Gibbons BJ, Roach PJ, Hurley TD2002 May 3112051921
RHEA:23360 L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2]
Reaction
Core-to-Core More
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle.Pitcher J, Smythe C, Cohen P1988 Sep 152970965
Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism.Mu J, Roach PJ1998 Dec 259857012
A precursor of glycogen biosynthesis: alpha-1,4-glucan-protein.Krisman CR, Barengo R1975 Mar 3809265
Catalytic activities of glycogenin additional to autocatalytic self-glucosylation.Alonso MD, Lomako J, Lomako WM, Whelan WJ1995 Jun 237797519
A new look at the biogenesis of glycogen.Alonso MD, Lomako J, Lomako WM, Whelan WJ1995 Sep7672505
A novel glycosyl-amino acid linkage: rabbit-muscle glycogen is covalently linked to a protein via tyrosine.Rodriguez IR, Whelan WJ1985 Oct 304062948
Identification of the 38-kDa subunit of rabbit skeletal muscle glycogen synthase as glycogenin.Pitcher J, Smythe C, Campbell DG, Cohen P1987 Dec 153121316
A self-glucosylating protein is the primer for rabbit muscle glycogen biosynthesis.Lomako J, Lomako WM, Whelan WJ1988 Dec2973423
Structural basis for the recruitment of glycogen synthase by glycogenin.Zeqiraj E, Tang X, Hunter RW, García-Rocha M, Judd A, Deak M, von Wilamowitz-Moellendorff A, Kurinov I, Guinovart JJ, Tyers M, Sakamoto K, Sicheri F2014 Jul 1524982189
Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin.Gibbons BJ, Roach PJ, Hurley TD2002 May 3112051921