EC number:2.4.1.212
| ID: | 2.4.1.212 |
|---|---|
| Description: | Hyaluronan synthase. |
| Alternative Name: |
HAS. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.212 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.212 |
| KEGG Enzyme Link: | KEGG2.4.1.212 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.212 |
| ExPASy Enzyme Link: | ExPASy2.4.1.212 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.212 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.212 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.212 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.212 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.212 |
EC number:2.4.1.212
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:20465 | [hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family. | Spicer AP, McDonald JA | 1998 Jan 23 | 9442026 |
| Molecular cloning, identification, and sequence of the hyaluronan synthase gene from group A Streptococcus pyogenes. | DeAngelis PL, Papaconstantinou J, Weigel PH | 1993 Sep 15 | 8366070 |
| Characterization of the purified hyaluronan synthase from Streptococcus equisimilis. | Tlapak-Simmons VL, Baron CA, Weigel PH | 2004 Jul 20 | 15248781 |
| Dissection of the two transferase activities of the Pasteurella multocida hyaluronan synthase: two active sites exist in one polypeptide. | Jing W, DeAngelis PL | 2000 Sep | 10988250 |
| Molecular directionality of polysaccharide polymerization by the Pasteurella multocida hyaluronan synthase. | DeAngelis PL | 1999 Sep 10 | 10473619 |
| Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. | Itano N, Sawai T, Yoshida M, Lenas P, Yamada Y, Imagawa M, Shinomura T, Hamaguchi M, Yoshida Y, Ohnuki Y, Miyauchi S, Spicer AP, McDonald JA, Kimata K | 1999 Aug 27 | 10455188 |
| RHEA:12528 | N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate = [hyaluronan](n+1) + H(+) + UDP |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[*:6]-[OH;+0:7]>>[*:6]-[O;H0;+0:7]-[CH;+0:2](-[*:1])-[*:3].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family. | Spicer AP, McDonald JA | 1998 Jan 23 | 9442026 |
| Molecular cloning, identification, and sequence of the hyaluronan synthase gene from group A Streptococcus pyogenes. | DeAngelis PL, Papaconstantinou J, Weigel PH | 1993 Sep 15 | 8366070 |
| Characterization of the purified hyaluronan synthase from Streptococcus equisimilis. | Tlapak-Simmons VL, Baron CA, Weigel PH | 2004 Jul 20 | 15248781 |
| Dissection of the two transferase activities of the Pasteurella multocida hyaluronan synthase: two active sites exist in one polypeptide. | Jing W, DeAngelis PL | 2000 Sep | 10988250 |
| Molecular directionality of polysaccharide polymerization by the Pasteurella multocida hyaluronan synthase. | DeAngelis PL | 1999 Sep 10 | 10473619 |
| Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. | Itano N, Sawai T, Yoshida M, Lenas P, Yamada Y, Imagawa M, Shinomura T, Hamaguchi M, Yoshida Y, Ohnuki Y, Miyauchi S, Spicer AP, McDonald JA, Kimata K | 1999 Aug 27 | 10455188 |