EC number:2.4.1.223
| ID: | 2.4.1.223 |
|---|---|
| Description: | acetylglucosaminyltransferase. |
| Alternative Name: |
Glucuronyl-galactosyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase. Glucuronosylgalactosyl-proteoglycan 4-alpha-N- Alpha-N-acetylglucosaminyltransferase I. Alpha-1,4-N-acetylglucosaminyltransferase. |
| Cath: | 3.90.550.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.223 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.223 |
| KEGG Enzyme Link: | KEGG2.4.1.223 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.223 |
| ExPASy Enzyme Link: | ExPASy2.4.1.223 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.223 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.223 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.223 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.223 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.223 |
EC number:2.4.1.223
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:16221 | 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:6]-[O;H0;+0:7]-[CH;+0:3](-[*:4])-[*:5].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis. | Pedersen LC, Dong J, Taniguchi F, Kitagawa H, Krahn JM, Pedersen LG, Sugahara K, Negishi M | 2003 Apr 18 | 12562774 |
| Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation. | Kim BT, Kitagawa H, Tamura Ji J, Kusche-Gullberg M, Lindahl U, Sugahara K | 2002 Apr 19 | 11832488 |
| rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate. | Kitagawa H, Egusa N, Tamura JI, Kusche-Gullberg M, Lindahl U, Sugahara K | 2001 Feb 16 | 11121397 |
| The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate. | Kitagawa H, Shimakawa H, Sugahara K | 1999 May 14 | 10318803 |