EC number:2.4.1.226

Enzyme

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     2. Transferases
        2.4 Glycosyltransferases
            2.4.1 Hexosyltransferases
ID:2.4.1.226
Description:N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase.
Alternative Name: Chondroitin glucuronyltransferase II.
Cath: 3.90.550.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.4.1.226
BRENDA Enzyme Link: BRENDA 2.4.1.226
KEGG Enzyme Link: KEGG2.4.1.226
BioCyc Enzyme Link: BioCyc 2.4.1.226
ExPASy Enzyme Link: ExPASy2.4.1.226
EC2PDB Enzyme Link: EC2PDB 2.4.1.226
ExplorEnz Enzyme Link: ExplorEnz 2.4.1.226
PRIAM enzyme-specific profiles Link: PRIAM 2.4.1.226
IntEnz Enzyme Link: IntEnz 2.4.1.226
MEDLINE Enzyme Link: MEDLINE 2.4.1.226

EC number:2.4.1.226

MSA:

2.4.1.226;
Phylogenetic Tree:

2.4.1.226;
Uniprot:
M-CSA:
RHEA:54996 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[*:6]-[OH;+0:7]>>[*:6]-[O;H0;+0:7]-[CH;+0:2](-[*:1])-[*:3].[*:5]-[OH;+0:4]
Reaction
Core-to-Core More
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4.Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K2002 Jun 1411943778
Molecular cloning and expression of a human chondroitin synthase.Kitagawa H, Uyama T, Sugahara K2001 Oct 1911514575
Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F.DeAngelis PL, Padgett-McCue AJ2000 Aug 410818104
Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine.Gotoh M, Yada T, Sato T, Akashima T, Iwasaki H, Mochizuki H, Inaba N, Togayachi A, Kudo T, Watanabe H, Kimata K, Narimatsu H2002 Oct 1112145278
RHEA:23428 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[*:6]-[OH;+0:7]>>[*:6]-[O;H0;+0:7]-[CH;+0:2](-[*:1])-[*:3].[*:5]-[OH;+0:4]
Reaction
Core-to-Core More
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4.Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K2002 Jun 1411943778
Molecular cloning and expression of a human chondroitin synthase.Kitagawa H, Uyama T, Sugahara K2001 Oct 1911514575
Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F.DeAngelis PL, Padgett-McCue AJ2000 Aug 410818104
Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine.Gotoh M, Yada T, Sato T, Akashima T, Iwasaki H, Mochizuki H, Inaba N, Togayachi A, Kudo T, Watanabe H, Kimata K, Narimatsu H2002 Oct 1112145278