EC number:2.4.1.228

Enzyme

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     2. Transferases
        2.4 Glycosyltransferases
            2.4.1 Hexosyltransferases
ID:2.4.1.228
Description:Lactosylceramide 4-alpha-galactosyltransferase.
Alternative Name: Histo-blood group P(k) UDP-galactose.
Globotriaosylceramide/CD77 synthase.
Gal-beta-1-4Glc-beta-1-Cer alpha-1,4-galactosyltransferase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.4.1.228
BRENDA Enzyme Link: BRENDA 2.4.1.228
KEGG Enzyme Link: KEGG2.4.1.228
BioCyc Enzyme Link: BioCyc 2.4.1.228
ExPASy Enzyme Link: ExPASy2.4.1.228
EC2PDB Enzyme Link: EC2PDB 2.4.1.228
ExplorEnz Enzyme Link: ExplorEnz 2.4.1.228
PRIAM enzyme-specific profiles Link: PRIAM 2.4.1.228
IntEnz Enzyme Link: IntEnz 2.4.1.228
MEDLINE Enzyme Link: MEDLINE 2.4.1.228

EC number:2.4.1.228

MSA:

2.4.1.228;
Phylogenetic Tree:

2.4.1.228;
Uniprot:
M-CSA:
RHEA:11924 beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) + UDP-alpha-D-galactose = globoside Gb3Cer (d18:1(4E)) + H(+) + UDP
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:6]-[O;H0;+0:7]-[CH;+0:3](-[*:4])-[*:5].[*:1]-[OH;+0:2]
Reaction
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References

TitleAuthorsDatePubMed ID
Identification of UDP-galactose: lactose (lactosylceramide) alpha-4 and beta-3 galactosyltransferases in human kidney.Bailly P, Piller F, Cartron JP, Leroy Y, Fournet B1986 Nov 263099784
Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals.Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU2000 Aug 1810854428
Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids.Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K2000 May 1910748143
Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype.Steffensen R, Carlier K, Wiels J, Levery SB, Stroud M, Cedergren B, Nilsson Sojka B, Bennett EP, Jersild C, Clausen H2000 Jun 210747952