EC number:2.4.1.255
| ID: | 2.4.1.255 |
|---|---|
| Description: | Protein O-GlcNAc transferase. |
| Alternative Name: |
OGTase. O-linked N-acetylglucosaminyltransferase. |
| Cath: | 3.30.720.150; 1.25.40.10; 3.40.50.11380; 3.40.50.20; 3.40.50.200; 3.40.50.2000; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.255 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.255 |
| KEGG Enzyme Link: | KEGG2.4.1.255 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.255 |
| ExPASy Enzyme Link: | ExPASy2.4.1.255 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.255 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.255 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.255 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.255 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.255 |
EC number:2.4.1.255
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:48908 | L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. | Lubas WA, Frank DW, Krause M, Hanover JA | 1997 Apr 4 | 9083068 |
| O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1. | Sakaidani Y, Ichiyanagi N, Saito C, Nomura T, Ito M, Nishio Y, Nadano D, Matsuda T, Furukawa K, Okajima T | 2012 Mar 2 | 22310717 |
| O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions. | Sakaidani Y, Nomura T, Matsuura A, Ito M, Suzuki E, Murakami K, Nadano D, Matsuda T, Furukawa K, Okajima T | 2011 Dec 13 | 22158438 |
| Structure of human O-GlcNAc transferase and its complex with a peptide substrate. | Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S | 2011 Jan 27 | 21240259 |
| Molecular characterization of nucleocytosolic O-GlcNAc transferases of Giardia lamblia and Cryptosporidium parvum. | Banerjee S, Robbins PW, Samuelson J | 2009 Apr | 18948359 |
| Structural insights into mechanism and specificity of O-GlcNAc transferase. | Clarke AJ, Hurtado-Guerrero R, Pathak S, Schüttelkopf AW, Borodkin V, Shepherd SM, Ibrahim AF, van Aalten DM | 2008 Oct 22 | 18818698 |
| Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis. | Rao FV, Dorfmueller HC, Villa F, Allwood M, Eggleston IM, van Aalten DM | 2006 Apr 5 | 16541109 |
| Glycosylation of nuclear and cytoplasmic proteins. Purification and characterization of a uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase. | Haltiwanger RS, Blomberg MA, Hart GW | 1992 May 5 | 1533623 |
| RHEA:48904 | L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. | Lubas WA, Frank DW, Krause M, Hanover JA | 1997 Apr 4 | 9083068 |
| O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1. | Sakaidani Y, Ichiyanagi N, Saito C, Nomura T, Ito M, Nishio Y, Nadano D, Matsuda T, Furukawa K, Okajima T | 2012 Mar 2 | 22310717 |
| O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions. | Sakaidani Y, Nomura T, Matsuura A, Ito M, Suzuki E, Murakami K, Nadano D, Matsuda T, Furukawa K, Okajima T | 2011 Dec 13 | 22158438 |
| Structure of human O-GlcNAc transferase and its complex with a peptide substrate. | Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S | 2011 Jan 27 | 21240259 |
| Molecular characterization of nucleocytosolic O-GlcNAc transferases of Giardia lamblia and Cryptosporidium parvum. | Banerjee S, Robbins PW, Samuelson J | 2009 Apr | 18948359 |
| Structural insights into mechanism and specificity of O-GlcNAc transferase. | Clarke AJ, Hurtado-Guerrero R, Pathak S, Schüttelkopf AW, Borodkin V, Shepherd SM, Ibrahim AF, van Aalten DM | 2008 Oct 22 | 18818698 |
| Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis. | Rao FV, Dorfmueller HC, Villa F, Allwood M, Eggleston IM, van Aalten DM | 2006 Apr 5 | 16541109 |
| Glycosylation of nuclear and cytoplasmic proteins. Purification and characterization of a uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase. | Haltiwanger RS, Blomberg MA, Hart GW | 1992 May 5 | 1533623 |