Enzyme

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EC Tree
     2. Transferases
        2.4 Glycosyltransferases
            2.4.1 Hexosyltransferases
ID:2.4.1.277
Description:10-deoxymethynolide desosaminyltransferase.
Alternative Name: Glycosyltransferase DesVII.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 2.4.1.277
BRENDA Enzyme Link: BRENDA 2.4.1.277
KEGG Enzyme Link: KEGG2.4.1.277
BioCyc Enzyme Link: BioCyc 2.4.1.277
ExPASy Enzyme Link: ExPASy2.4.1.277
EC2PDB Enzyme Link: EC2PDB 2.4.1.277
ExplorEnz Enzyme Link: ExplorEnz 2.4.1.277
PRIAM enzyme-specific profiles Link: PRIAM 2.4.1.277
IntEnz Enzyme Link: IntEnz 2.4.1.277
MEDLINE Enzyme Link: MEDLINE 2.4.1.277
MSA:

2.4.1.277;

Phylogenetic Tree:

2.4.1.277;

Uniprot:
M-CSA:
RHEA:31627 10-deoxymethynolide + dTDP-alpha-D-desosamine = 10-deoxymethymycin + dTDP + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2]
Reaction
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References

TitleAuthorsDatePubMed ID
Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway.Borisova SA, Liu HW2010 Sep 2120695498
Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications.Borisova SA, Kim HJ, Pu X, Liu HW2008 Jul 218548476
Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation.Hong JS, Park SJ, Parajuli N, Park SR, Koh HS, Jung WS, Choi CY, Yoon YJ2007 Jan 1517049185
Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics.Borisova SA, Zhao L, Melançon III CE, Kao CL, Liu HW2004 Jun 215161264