EC number:2.4.1.278

Enzyme

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     2. Transferases
        2.4 Glycosyltransferases
            2.4.1 Hexosyltransferases
ID:2.4.1.278
Description:3-alpha-mycarosylerythronolide B desosaminyl transferase.
Alternative Name: EryCIII.
Desosaminyl transferase EryCIII.
Cath: 3.40.50.11450; 3.40.50.20; 3.40.50.200; 3.40.50.2000;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.4.1.278
BRENDA Enzyme Link: BRENDA 2.4.1.278
KEGG Enzyme Link: KEGG2.4.1.278
BioCyc Enzyme Link: BioCyc 2.4.1.278
ExPASy Enzyme Link: ExPASy2.4.1.278
EC2PDB Enzyme Link: EC2PDB 2.4.1.278
ExplorEnz Enzyme Link: ExplorEnz 2.4.1.278
PRIAM enzyme-specific profiles Link: PRIAM 2.4.1.278
IntEnz Enzyme Link: IntEnz 2.4.1.278
MEDLINE Enzyme Link: MEDLINE 2.4.1.278

EC number:2.4.1.278

MSA:

2.4.1.278;
Phylogenetic Tree:

2.4.1.278;
Uniprot:
M-CSA:
RHEA:32091 3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine = dTDP + erythromycin D + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:6]-[O;H0;+0:7]-[CH;+0:3](-[*:4])-[*:5].[*:1]-[OH;+0:2]
Reaction
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References

TitleAuthorsDatePubMed ID
In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides.Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S2005 Oct 1916218575
Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway.Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S2004 Aug 1815303858