EC number:2.4.1.301
| ID: | 2.4.1.301 |
|---|---|
| Description: | 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.301 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.301 |
| KEGG Enzyme Link: | KEGG2.4.1.301 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.301 |
| ExPASy Enzyme Link: | ExPASy2.4.1.301 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.301 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.301 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.301 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.301 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.301 |
EC number:2.4.1.301
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:35783 | neamine + UDP-alpha-D-kanosamine = H(+) + kanamycin B + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the α-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK. | Sucipto H, Kudo F, Eguchi T | 2012 Apr 2 | 22374809 |
| Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. | Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ | 2011 Oct 9 | 21983602 |
| Enzymatic activity of a glycosyltransferase KanM2 encoded in the kanamycin biosynthetic gene cluster. | Kudo F, Sucipto H, Eguchi T | 2009 Dec | 19911031 |
| RHEA:35787 | paromamine + UDP-alpha-D-kanosamine = H(+) + kanamycin C + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the α-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK. | Sucipto H, Kudo F, Eguchi T | 2012 Apr 2 | 22374809 |
| Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. | Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ | 2011 Oct 9 | 21983602 |
| Enzymatic activity of a glycosyltransferase KanM2 encoded in the kanamycin biosynthetic gene cluster. | Kudo F, Sucipto H, Eguchi T | 2009 Dec | 19911031 |
| RHEA:35791 | 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine = H(+) + kanamycin X + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the α-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK. | Sucipto H, Kudo F, Eguchi T | 2012 Apr 2 | 22374809 |
| Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. | Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ | 2011 Oct 9 | 21983602 |
| Enzymatic activity of a glycosyltransferase KanM2 encoded in the kanamycin biosynthetic gene cluster. | Kudo F, Sucipto H, Eguchi T | 2009 Dec | 19911031 |
| RHEA:35795 | 2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine = H(+) + kanamycin A + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the α-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK. | Sucipto H, Kudo F, Eguchi T | 2012 Apr 2 | 22374809 |
| Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. | Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ | 2011 Oct 9 | 21983602 |
| Enzymatic activity of a glycosyltransferase KanM2 encoded in the kanamycin biosynthetic gene cluster. | Kudo F, Sucipto H, Eguchi T | 2009 Dec | 19911031 |