ID: | 2.4.1.345 |
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Description: | Phosphatidyl-myo-inositol alpha-mannosyltransferase. |
Alternative Name: |
mannosyltransferase. Guanosine diphosphomannose-phosphatidyl-inositol alpha- |
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.UniProtKB Enzyme Link: | UniProtKB 2.4.1.345 |
BRENDA Enzyme Link: | BRENDA 2.4.1.345 |
KEGG Enzyme Link: | KEGG2.4.1.345 |
BioCyc Enzyme Link: | BioCyc 2.4.1.345 |
ExPASy Enzyme Link: | ExPASy2.4.1.345 |
EC2PDB Enzyme Link: | EC2PDB 2.4.1.345 |
ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.345 |
PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.345 |
IntEnz Enzyme Link: | IntEnz 2.4.1.345 |
MEDLINE Enzyme Link: | MEDLINE 2.4.1.345 |
MSA: | |
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Phylogenetic Tree: | |
Uniprot: | |
M-CSA: |
RHEA:47368 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose = 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + GDP + H(+) |
RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
Reaction | ![]() |
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Title | Authors | Date | PubMed ID |
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Secondary structure reshuffling modulates glycosyltransferase function at the membrane. | Giganti D, Albesa-Jové D, Urresti S, Rodrigo-Unzueta A, Martínez MA, Comino N, Barilone N, Bellinzoni M, Chenal A, Guerin ME, Alzari PM | 2015 Jan | 25402770 |
Expression and purification of a functionally active recombinant GDP-mannosyltransferase (PimA) from Mycobacterium tuberculosis H37Rv. | Gu X, Chen M, Wang Q, Zhang M, Wang B, Wang H | 2005 Jul | 15939292 |
Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria. | Korduláková J, Gilleron M, Mikusova K, Puzo G, Brennan PJ, Gicquel B, Jackson M | 2002 Aug 30 | 12068013 |