Enzyme

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     2. Transferases
        2.4 Glycosyltransferases
            2.4.1 Hexosyltransferases
ID:2.4.1.345
Description:Phosphatidyl-myo-inositol alpha-mannosyltransferase.
Alternative Name: mannosyltransferase.
Guanosine diphosphomannose-phosphatidyl-inositol alpha-

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 2.4.1.345
BRENDA Enzyme Link: BRENDA 2.4.1.345
KEGG Enzyme Link: KEGG2.4.1.345
BioCyc Enzyme Link: BioCyc 2.4.1.345
ExPASy Enzyme Link: ExPASy2.4.1.345
EC2PDB Enzyme Link: EC2PDB 2.4.1.345
ExplorEnz Enzyme Link: ExplorEnz 2.4.1.345
PRIAM enzyme-specific profiles Link: PRIAM 2.4.1.345
IntEnz Enzyme Link: IntEnz 2.4.1.345
MEDLINE Enzyme Link: MEDLINE 2.4.1.345
MSA:

2.4.1.345;

Phylogenetic Tree:

2.4.1.345;

Uniprot:
M-CSA:
RHEA:47368 a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose = 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + GDP + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2]
Reaction
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References

TitleAuthorsDatePubMed ID
Secondary structure reshuffling modulates glycosyltransferase function at the membrane.Giganti D, Albesa-Jové D, Urresti S, Rodrigo-Unzueta A, Martínez MA, Comino N, Barilone N, Bellinzoni M, Chenal A, Guerin ME, Alzari PM2015 Jan25402770
Expression and purification of a functionally active recombinant GDP-mannosyltransferase (PimA) from Mycobacterium tuberculosis H37Rv.Gu X, Chen M, Wang Q, Zhang M, Wang B, Wang H2005 Jul15939292
Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria.Korduláková J, Gilleron M, Mikusova K, Puzo G, Brennan PJ, Gicquel B, Jackson M2002 Aug 3012068013