EC number:2.4.1.346
| ID: | 2.4.1.346 |
|---|---|
| Description: | Phosphatidyl-myo-inositol dimannoside synthase. |
| Alternative Name: |
mannosyltransferase. Guanosine diphosphomannose-phosphatidyl-inositol alpha- |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.346 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.346 |
| KEGG Enzyme Link: | KEGG2.4.1.346 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.346 |
| ExPASy Enzyme Link: | ExPASy2.4.1.346 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.346 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.346 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.346 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.346 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.346 |
EC number:2.4.1.346
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:52444 | 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1->2)-D-myo-inositol] + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:6]-[O;H0;+0:7]-[CH;+0:3](-[*:4])-[*:5].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'. | Batt SM, Jabeen T, Mishra AK, Veerapen N, Krumbach K, Eggeling L, Besra GS, Fütterer K | 2010 Nov 26 | 20843801 |
| New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB' is an essential enzyme of Mycobacterium smegmatis. | Guerin ME, Kaur D, Somashekar BS, Gibbs S, Gest P, Chatterjee D, Brennan PJ, Jackson M | 2009 Sep 18 | 19638342 |
| Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis. | Mishra AK, Batt S, Krumbach K, Eggeling L, Besra GS | 2009 Jul | 19395496 |
| RHEA:52440 | 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + GDP-alpha-D-mannose = a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'. | Batt SM, Jabeen T, Mishra AK, Veerapen N, Krumbach K, Eggeling L, Besra GS, Fütterer K | 2010 Nov 26 | 20843801 |
| New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB' is an essential enzyme of Mycobacterium smegmatis. | Guerin ME, Kaur D, Somashekar BS, Gibbs S, Gest P, Chatterjee D, Brennan PJ, Jackson M | 2009 Sep 18 | 19638342 |
| Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis. | Mishra AK, Batt S, Krumbach K, Eggeling L, Besra GS | 2009 Jul | 19395496 |