EC number:2.4.1.40
| ID: | 2.4.1.40 |
|---|---|
| Description: | Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase. |
| Alternative Name: |
Histo-blood group A transferase. Histo-blood group A acetylgalactosaminyltransferase. Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase. Fucosylgalactose alpha-N-acetylgalactosaminyltransferase. A transferase. |
| Cath: | 3.90.550.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.40 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.40 |
| KEGG Enzyme Link: | KEGG2.4.1.40 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.40 |
| ExPASy Enzyme Link: | ExPASy2.4.1.40 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.40 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.40 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.40 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.40 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.40 |
| RHEA:19021 | an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine = a N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactose group + H(+) + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterisation of a blood-group A-active tetrasaccharide synthesised by a blood-group B gene-specified glycosyltransferase. | Yates AD, Feeney J, Donald AS, Watkins WM | 1984 Jul 15 | 6434182 |
| Complete purification and characterization of alpha-3-N-acetylgalactosaminyltransferase encoded by the human blood group A gene. | Takeya A, Hosomi O, Ishiura M | 1990 Mar | 2341371 |
| Structural effects of naturally occurring human blood group B galactosyltransferase mutations adjacent to the DXD motif. | Persson M, Letts JA, Hosseini-Maaf B, Borisova SN, Palcic MM, Evans SV, Olsson ML | 2007 Mar 30 | 17259183 |
| The structural basis for specificity in human ABO(H) blood group biosynthesis. | Patenaude SI, Seto NO, Borisova SN, Szpacenko A, Marcus SL, Palcic MM, Evans SV | 2002 Sep | 12198488 |