EC number:2.4.1.47
| ID: | 2.4.1.47 |
|---|---|
| Description: | N-acylsphingosine galactosyltransferase. |
| Alternative Name: |
2-hydroxyacylsphingosine 1-beta-galactosyltransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.47 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.47 |
| KEGG Enzyme Link: | KEGG2.4.1.47 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.47 |
| ExPASy Enzyme Link: | ExPASy2.4.1.47 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.47 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.47 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.47 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.47 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.47 |
| RHEA:13093 | an N-acylsphing-4-enine + UDP-alpha-D-galactose = an N-acyl-beta-D-galactosyl-sphing-4-enine + H(+) + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymic synthesis of cerebroside from ceramide and uridine diphosphate galactose. | Fujino Y, Nakano M | 1969 Jul | 5807218 |
| RHEA:10856 | a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose = a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + H(+) + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum. | Sprong H, Kruithof B, Leijendekker R, Slot JW, van Meer G, van der Sluijs P | 1998 Oct 2 | 9748263 |
| Ceramide UDPgalactosyltransferase from myelinating rat brain: purification, cloning, and expression. | Schulte S, Stoffel W | 1993 Nov 1 | 7694285 |
| UDP-galactose:ceramide galactosyltransferase of rat central-nervous-system myelin. | Koul O, Jungalwala FB | 1981 Feb 15 | 7306007 |
| Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing hydroxy fatty acid. | Morell P, Radin NS | 1969 Feb | 5793706 |
| The biosynthesis by brain microsomes of cerebrosides containing nonhydroxy fatty acids. | Morell P, Costantino-Ceccarini E, Radin NS | 1970 Dec | 5497154 |
| Enzymatic synthesis of galactocerebroside by a galactosyltransferase from embryonic chicken brain. | Basu S, Schultz AM, Basu M, Roseman S | 1971 Jul 10 | 5090043 |
| Reversal of non-hydroxy:alpha-hydroxy galactosylceramide ratio and unstable myelin in transgenic mice overexpressing UDP-galactose:ceramide galactosyltransferase. | Fewou SN, Büssow H, Schaeren-Wiemers N, Vanier MT, Macklin WB, Gieselmann V, Eckhardt M | 2005 Jul | 15998297 |