EC number:2.4.1.65
| ID: | 2.4.1.65 |
|---|---|
| Description: | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase. |
| Alternative Name: |
Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase. Lewis FT. Lewis blood group alpha-(1->3/4)-fucosyltransferase. Lewis alpha-(1->3/4)-fucosyltransferase. Guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase. Guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase. fucosyltransferase. Guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L- Galactoside 3(4)-L-fucosyltransferase. FucT-II. Blood-group substance Le(a)-dependent fucosyltransferase. Blood group Lewis alpha-4-fucosyltransferase. Beta-acetylglucosaminylsaccharide fucosyltransferase. Alpha-4-L-fucosyltransferase. Alpha-(1->4)-L-fucosyltransferase. Alpha(1,3/1,4) fucosyltransferase III. (Le(a))-dependent (alpha-3/4)-fucosyltransferase. |
| Cath: | 3.40.50.11650; 3.40.50.11660; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.65 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.65 |
| KEGG Enzyme Link: | KEGG2.4.1.65 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.65 |
| ExPASy Enzyme Link: | ExPASy2.4.1.65 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.65 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.65 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.65 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.65 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.65 |
| RHEA:23628 | a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer. | Ma B, Wang G, Palcic MM, Hazes B, Taylor DE | 2003 Jun 13 | 12676935 |
| Co-purification of the Lewis blood group N-acetylglucosaminide alpha 1 goes to 4 fucosyltransferase and an N-acetylglucosaminide alpha 1 goes to 3 fucosyltransferase from human milk. | Prieels JP, Monnom D, Dolmans M, Beyer TA, Hill RL | 1981 Oct 25 | 7287719 |
| Identification of a cDNA encoding a plant Lewis-type alpha1,4-fucosyltransferase. | Wilson IB | 2001 Jun | 12084979 |
| Cloning and characterization of the alpha(1,3/4) fucosyltransferase of Helicobacter pylori. | Rasko DA, Wang G, Palcic MM, Taylor DE | 2000 Feb 18 | 10671538 |