EC number:2.4.1.69
| ID: | 2.4.1.69 |
|---|---|
| Description: | Type 1 galactoside alpha-(1,2)-fucosyltransferase. |
| Alternative Name: |
Secretor-type beta-galactoside alpha-1->2 fucosyltransferase. Guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase. Guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase. fucosyltransferase. galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L- Guanosine diphosphofucose- Guanosine diphosphofucose-galactoside 2-L-fucosyltransferase. Guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase. Galactoside 2-alpha-L-fucosyltransferase. Blood-group substance H-dependent fucosyltransferase. Blood group H alpha-2-fucosyltransferase. Beta-galactoside alpha-1->2 fucosyltransferase. Alpha-2-L-fucosyltransferase. Alpha-2-fucosyltransferase. Alpha-(1->2)-L-fucosyltransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.69 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.69 |
| KEGG Enzyme Link: | KEGG2.4.1.69 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.69 |
| ExPASy Enzyme Link: | ExPASy2.4.1.69 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.69 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.69 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.69 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.69 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.69 |
| RHEA:50664 | a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| An amino acid region at the N-terminus of rat hepatoma alpha1-->2 fucosyltransferase modulates enzyme activity and interaction with lipids: strong preference for glycosphingolipids containing terminal Galbeta1-->3GalNAc-structures. | Sherwood AL, Stroud MR, Levery SB, Holmes EH | 2001 May 15 | 11341836 |
| Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2). | Koda Y, Soejima M, Wang B, Kimura H | 1997 Jun 15 | 9219535 |
| Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. | Kelly RJ, Rouquier S, Giorgi D, Lennon GG, Lowe JB | 1995 Mar 3 | 7876235 |
| Molecular cloning and expression of two types of rabbit beta-galactoside alpha 1,2-fucosyltransferase. | Hitoshi S, Kusunoki S, Kanazawa I, Tsuji S | 1995 Apr 14 | 7721792 |
| Porcine submaxillary gland GDP-L-fucose: beta-D-galactoside alpha-2-L-fucosyltransferase is likely a counterpart of the human Secretor gene-encoded blood group transferase. | Thurin J, Blaszczyk-Thurin M | 1995 Nov 3 | 7592879 |
| Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase. | Kumazaki T, Yoshida A | 1984 Jul | 6588382 |
| A non-Golgi alpha 1,2-fucosyltransferase that modifies Skp1 in the cytoplasm of Dictyostelium. | van Der Wel H, Morris HR, Panico M, Paxton T, North SJ, Dell A, Thomson JM, West CM | 2001 Sep 7 | 11423539 |
| Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract. | Domino SE, Zhang L, Lowe JB | 2001 Jun 29 | 11323419 |
| Comparison of the three rat GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferases FTA, FTB and FTC. | Bureau V, Marionneau S, Cailleau-Thomas A, Le Moullac-Vaidye B, Liehr T, Le Pendu J | 2001 Feb | 11179967 |
| A DNA polymorphism influencing alpha(1,2)fucosyltransferase activity of the pig FUT1 enzyme determines susceptibility of small intestinal epithelium to Escherichia coli F18 adhesion. | Meijerink E, Neuenschwander S, Fries R, Dinter A, Bertschinger HU, Stranzinger G, Vögeli P | 2000 Nov | 11132149 |
| Novel Helicobacter pylori alpha1,2-fucosyltransferase, a key enzyme in the synthesis of Lewis antigens. | Wang G, Boulton PG, Chan NW, Palcic MM, Taylor DE | 1999 Nov | 10589734 |
| Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland. | Beyer TA, Hill RL | 1980 Jun 10 | 7372640 |
| Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland. | Beyer TA, Sadler JE, Hill RL | 1980 Jun 10 | 6246105 |
| RHEA:32175 | beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-N-acylsphing-4-enine + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+) |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[*:6]-[OH;+0:7]>>[*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:7]-[*:6].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland. | Beyer TA, Hill RL | 1980 Jun 10 | 7372640 |
| Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland. | Beyer TA, Sadler JE, Hill RL | 1980 Jun 10 | 6246105 |
| Tissue-specific loss of fucosylated glycolipids in mice with targeted deletion of alpha(1,2)fucosyltransferase genes. | Iwamori M, Domino SE | 2004 May 15 | 14967068 |
| Characterization of three members of murine alpha1,2-fucosyltransferases: change in the expression of the Se gene in the intestine of mice after administration of microbes. | Lin B, Saito M, Sakakibara Y, Hayashi Y, Yanagisawa M, Iwamori M | 2001 Apr 15 | 11368156 |