EC number:2.4.1.80
| ID: | 2.4.1.80 |
|---|---|
| Description: | Ceramide glucosyltransferase. |
| Alternative Name: |
UDP-glucose-ceramide glucosyltransferase. Glucosylceramide synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.80 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.80 |
| KEGG Enzyme Link: | KEGG2.4.1.80 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.80 |
| ExPASy Enzyme Link: | ExPASy2.4.1.80 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.80 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.80 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.80 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.80 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.80 |
| RHEA:12088 | an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:4]-[CH;+0:3](-[*:5])-[O;H0;+0:7]-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis. | Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y | 1996 May 14 | 8643456 |
| Purification and characterization of UDP-glucose:ceramide glucosyltransferase from rat liver Golgi membranes. | Paul P, Kamisaka Y, Marks DL, Pagano RE | 1996 Jan 26 | 8567691 |
| Cloning and functional characterization of two key enzymes of glycosphingolipid biosynthesis in the amphibian Xenopus laevis. | Luque ME, Crespo PM, Mónaco ME, Aybar MJ, Daniotti JL, Sánchez SS | 2008 Jan | 18095347 |
| The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs. | Veldman RJ, Mita A, Cuvillier O, Garcia V, Klappe K, Medin JA, Campbell JD, Carpentier S, Kok JW, Levade T | 2003 Jun | 12692077 |
| Histidine-193 of rat glucosylceramide synthase resides in a UDP-glucose- and inhibitor (D-threo-1-phenyl-2-decanoylamino-3-morpholinopropan-1-ol)-binding region: a biochemical and mutational study. | Wu K, Marks DL, Watanabe R, Paul P, Rajan N, Pagano RE | 1999 Jul 15 | 10393098 |