EC number:2.4.1.92
| ID: | 2.4.1.92 |
|---|---|
| Description: | N-acetylgalactosaminyltransferase. |
| Alternative Name: |
Uridine diphosphoacetylgalactosamine-hematoside Uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase. acetylneuraminylgalactosylglucosylceramide Uridine diphosphoacetylgalactosamine- UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase. glucosylceramide acetylgalactosaminyltransferase. UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D- GM2/GD2-synthase. GM2 synthase. Ganglioside GM3 acetylgalactosaminyltransferase. Ganglioside GM2 synthase. GalNAc-T. Beta-1,4N-aetylgalactosaminyltransferase. Asialo-GM2 synthase. |
3D structure
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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.1.92 |
| BRENDA Enzyme Link: | BRENDA 2.4.1.92 |
| KEGG Enzyme Link: | KEGG2.4.1.92 |
| BioCyc Enzyme Link: | BioCyc 2.4.1.92 |
| ExPASy Enzyme Link: | ExPASy2.4.1.92 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.1.92 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.1.92 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.1.92 |
| IntEnz Enzyme Link: | IntEnz 2.4.1.92 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.1.92 |
| RHEA:12588 | ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GM2 (d18:1(4E)) + H(+) + UDP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]>>[*:6]-[O;H0;+0:7]-[CH;+0:3](-[*:4])-[*:5].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of UDP-N-acetylgalactosamine GM3/GD3 N-acetylgalactosaminyltransferase from mouse liver. | Hashimoto Y, Sekine M, Iwasaki K, Suzuki A | 1993 Dec 5 | 8245020 |
| beta 1-4N-acetylgalactosaminyltransferase can synthesize both asialoglycosphingolipid GM2 and glycosphingolipid GM2 in vitro and in vivo: isolation and characterization of a beta 1-4N-acetylgalactosaminyltransferase cDNA clone from rat ascites hepatoma cell line AH7974F. | Hidari JK, Ichikawa S, Furukawa K, Yamasaki M, Hirabayashi Y | 1994 Nov 1 | 7980468 |
| The enzymic synthesis of ganglioside. IV. UDP-N-acetylgalactosamine: (N-acetylneuraminyl)-galactosylglucosyl ceramide N-acetylgalactosaminyltransferase in rat brain. | Dicesare JL, Dain JA | 1971 Mar 16 | 5554906 |
| Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver. | Pohlentz G, Klein D, Schwarzmann G, Schmitz D, Sandhoff K | 1988 Oct | 3140234 |
| Biosynthesis of monosulfogangliotriaosylceramide and GM2 by N-acetylgalactosaminyltransferase from rat brain. | Nagai K, Ishizuka I | 1987 May | 3115968 |
| Role of a single amino acid in the evolution of glycans of invertebrates and vertebrates. | Ramakrishnan B, Qasba PK | 2007 Jan 19 | 17084860 |
| Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions. | Yamashita T, Wu YP, Sandhoff R, Werth N, Mizukami H, Ellis JM, Dupree JL, Geyer R, Sandhoff K, Proia RL | 2005 Feb 22 | 15710896 |
| Beta1,4-N-acetylgalactosaminyltransferase--GM2/GD2 synthase: a key enzyme to control the synthesis of brain-enriched complex gangliosides. | Furukawa K, Takamiya K, Furukawa K | 2002 Dec 19 | 12417418 |