EC number:2.4.2.12
| ID: | 2.4.2.12 |
|---|---|
| Description: | Nicotinamide phosphoribosyltransferase. |
| Alternative Name: |
NMN pyrophosphorylase. NMN diphosphorylase. |
| Cath: | 3.20.20.70; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.2.12 |
| BRENDA Enzyme Link: | BRENDA 2.4.2.12 |
| KEGG Enzyme Link: | KEGG2.4.2.12 |
| BioCyc Enzyme Link: | BioCyc 2.4.2.12 |
| ExPASy Enzyme Link: | ExPASy2.4.2.12 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.2.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.2.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.2.12 |
| IntEnz Enzyme Link: | IntEnz 2.4.2.12 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.2.12 |
| RHEA:16149 | beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[n+;H0:4](:[*:5]):[*:6].[*:7]-[OH;+0:8]>>[*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:8]-[*:7].[*:5]:[n;H0;+0:4]:[*:6] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866. | Kim MK, Lee JH, Kim H, Park SJ, Kim SH, Kang GB, Lee YS, Kim JB, Kim KK, Suh SW, Eom SH | 2006 Sep 8 | 16901503 |
| Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. | Khan JA, Tao X, Tong L | 2006 Jul | 16783377 |
| Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. | Rongvaux A, Shea RJ, Mulks MH, Gigot D, Urbain J, Leo O, Andris F | 2002 Nov | 12555668 |