EC number:2.4.2.19
| ID: | 2.4.2.19 |
|---|---|
| Description: | Nicotinate-nucleotide diphosphorylase (carboxylating). |
| Alternative Name: |
Quinolinate phosphoribosyltransferase (decarboxylating). Nicotinate-nucleotide pyrophosphorylase (carboxylating). |
| Cath: | 3.20.20.70; 3.90.1170.20; 3.40.50.10800; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.2.19 |
| BRENDA Enzyme Link: | BRENDA 2.4.2.19 |
| KEGG Enzyme Link: | KEGG2.4.2.19 |
| BioCyc Enzyme Link: | BioCyc 2.4.2.19 |
| ExPASy Enzyme Link: | ExPASy2.4.2.19 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.2.19 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.2.19 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.2.19 |
| IntEnz Enzyme Link: | IntEnz 2.4.2.19 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.2.19 |
| RHEA:12733 | CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[n+;H0:4](:[*:5]):[cH;+0:6]:[*:7].[*:8]-[OH;+0:9].[*:10]=[C;H0;+0:11]=[O;H0;+0:12]>>[*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:9]-[*:8].[*:10]=[C;H0;+0:11](-[OH;+0:12])-[c;H0;+0:6](:[*:7]):[n;H0;+0:4]:[*:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens. | Liu H, Woznica K, Catton G, Crawford A, Botting N, Naismith JH | 2007 Oct 26 | 17868694 |
| Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori. | Kim MK, Im YJ, Lee JH, Eom SH | 2006 Apr 1 | 16419067 |
| Quinolinate phosphoribosyltransferase: kinetic mechanism for a type II PRTase. | Cao H, Pietrak BL, Grubmeyer C | 2002 Mar 12 | 11876660 |