EnzyMine

Download

EC Tree

2. Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

ID:

2.4.2.2

Description:

Pyrimidine-nucleoside phosphorylase.

Alternative Name:

Py-NPase.

Prosite:

PDOC00557;

PDB:

» show all

Cath:

3.40.1030.10; 3.90.1170.30; 1.20.970.10;

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

PDB	Click once to unfold,double click to fold. 2WK5; 2J0F; 2WK6; 1UOU; 1BRW; 1AZY; 4LHM; 4EAF; 4EAD; 2TPT; 1TPT; 1OTP; 5OLN; 5EY3; 5EP8; 4YYY; 4YEK; 4XR5; 4X46; 4GA6; 4GA5; 4GA4; 3H5Q;

UniProtKB Enzyme Link:	UniProtKB 2.4.2.2
BRENDA Enzyme Link:	BRENDA 2.4.2.2
KEGG Enzyme Link:	KEGG2.4.2.2
BioCyc Enzyme Link:	BioCyc 2.4.2.2
ExPASy Enzyme Link:	ExPASy2.4.2.2
EC2PDB Enzyme Link:	EC2PDB 2.4.2.2
ExplorEnz Enzyme Link:	ExplorEnz 2.4.2.2
PRIAM enzyme-specific profiles Link:	PRIAM 2.4.2.2
IntEnz Enzyme Link:	IntEnz 2.4.2.2
MEDLINE Enzyme Link:	MEDLINE 2.4.2.2

RHEA:24388	phosphate + uridine = alpha-D-ribose 1-phosphate + uracil
RULE(radius=1)	[:1]-[CH;+0:2](-[:3])-[n;H0;+0:4](:[:5]):[:6].[:7]-[OH;+0:8]>>[:1]-[CH;+0:2](-[:3])-[O;H0;+0:8]-[:7].[:5]:[nH;+0:4]:[:6]
Reaction
Core-to-Core	More
Core-to-Core	More

Title	Authors	Date	PubMed ID
Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli.	Sévin DC, Fuhrer T, Zamboni N, Sauer U	2017 Feb	27941785
Crystal structures of Escherichia coli uridine phosphorylase in two native and three complexed forms reveal basis of substrate specificity, induced conformational changes and influence of potassium.	Caradoc-Davies TT, Cutfield SM, Lamont IL, Cutfield JF	2004 Mar 19	15003451
Structure of Escherichia coli uridine phosphorylase at 2.0 A.	Burling FT, Kniewel R, Buglino JA, Chadha T, Beckwith A, Lima CD	2003 Jan	12499542

RHEA:22824	2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil
RULE(radius=1)	[:1]-[CH;+0:2](-[:3])-[n;H0;+0:4](:[:5]):[:6].[:7]-[OH;+0:8]>>[:1]-[CH;+0:2](-[:3])-[O;H0;+0:8]-[:7].[:5]:[nH;+0:4]:[:6]
Reaction
Core-to-Core	More
Core-to-Core	More

Title	Authors	Date	PubMed ID
The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation.	Pugmire MJ, Ealick SE	1998 Nov 15	9817849
Molecular cloning and expression of the pyrimidine nucleoside phosphorylase gene from Bacillus stearothermophilus TH 6-2.	Okuyama K, Hamamoto T, Noguchi T, Midorikawa Y	1996 Oct	8987664
Purification and characterization of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus TH 6-2.	Hamamoto T, Noguchi T, Midorikawa Y	1996 Jul	8782414
Purification and comparative properties of a pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus.	Saunders PP, Wilson BA, Saunders GF	1969 Jul 10	4978445

RHEA:16037	phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine
RULE(radius=1)	[:1]-[CH;+0:2](-[:3])-[n;H0;+0:4](:[:5]):[:6].[:7]-[OH;+0:8]>>[:1]-[CH;+0:2](-[:3])-[O;H0;+0:8]-[:7].[:5]:[nH;+0:4]:[:6]
Reaction
Core-to-Core	More
Core-to-Core	More

Title	Authors	Date	PubMed ID
The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation.	Pugmire MJ, Ealick SE	1998 Nov 15	9817849
Molecular cloning and expression of the pyrimidine nucleoside phosphorylase gene from Bacillus stearothermophilus TH 6-2.	Okuyama K, Hamamoto T, Noguchi T, Midorikawa Y	1996 Oct	8987664
Purification and characterization of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus TH 6-2.	Hamamoto T, Noguchi T, Midorikawa Y	1996 Jul	8782414
Purification and comparative properties of a pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus.	Saunders PP, Wilson BA, Saunders GF	1969 Jul 10	4978445
Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli.	Sévin DC, Fuhrer T, Zamboni N, Sauer U	2017 Feb	27941785