EC number:2.4.2.60

Enzyme

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     2. Transferases
        2.4 Glycosyltransferases
            2.4.2 Pentosyltransferases
ID:2.4.2.60
Description:Cysteine-dependent adenosine diphosphate thiazole synthase.
Alternative Name: ADP-thiazole synthase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.4.2.60
BRENDA Enzyme Link: BRENDA 2.4.2.60
KEGG Enzyme Link: KEGG2.4.2.60
BioCyc Enzyme Link: BioCyc 2.4.2.60
ExPASy Enzyme Link: ExPASy2.4.2.60
EC2PDB Enzyme Link: EC2PDB 2.4.2.60
ExplorEnz Enzyme Link: ExplorEnz 2.4.2.60
PRIAM enzyme-specific profiles Link: PRIAM 2.4.2.60
IntEnz Enzyme Link: IntEnz 2.4.2.60
MEDLINE Enzyme Link: MEDLINE 2.4.2.60

EC number:2.4.2.60

MSA:

2.4.2.60;
Phylogenetic Tree:

2.4.2.60;
Uniprot:
M-CSA:
RHEA:55708 [ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide
RULE(radius=1) [*:1]-[CH2;+0:2]-[NH2;+0:3].[*:4]-[CH;+0:5](-[*:6])-[CH2;+0:7]-[SH;+0:8].[*:9]-[CH;+0:10]1-[O;H0;+0:11]-[CH;+0:12](-[n+;H0:13](:[*:14]):[*:15])-[CH;+0:16](-[OH;+0:17])-[CH;+0:18]-1-[OH;+0:19]>>[*:4]-[C;H0;+0:5](-[*:6])=[CH2;+0:7].[*:9]-[CH2;+0:10]-[c;H0;+0:18]1:[s;H0;+0:8]:[c;H0;+0:2](-[*:1]):[n;H0;+0:3]:[c;H0;+0:16]:1-[CH3;+0:12].[*:14]:[n;H0;+0:13]:[*:15].[OH2;+0:19].[OH2;+0:17].[OH2;+0:11]
Reaction
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References

TitleAuthorsDatePubMed ID
From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis.Eser BE, Zhang X, Chanani PK, Begley TP, Ealick SE2016 Mar 2326928142
Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases.Zhang X, Eser BE, Chanani PK, Begley TP, Ealick SE2016 Mar 2926919468