EC number:2.4.99.17
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.4 Glycosyltransferases |
| 2.4.99 Transferring other glycosyl groups |
| ID: | 2.4.99.17 |
|---|---|
| Description: | S-adenosylmethionine:tRNA ribosyltransferase-isomerase. |
| Alternative Name: |
Queuosine biosynthesis protein QueA. |
| Cath: | 2.40.10.240; 3.40.1780.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.99.17 |
| BRENDA Enzyme Link: | BRENDA 2.4.99.17 |
| KEGG Enzyme Link: | KEGG2.4.99.17 |
| BioCyc Enzyme Link: | BioCyc 2.4.99.17 |
| ExPASy Enzyme Link: | ExPASy2.4.99.17 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.99.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.99.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.99.17 |
| IntEnz Enzyme Link: | IntEnz 2.4.99.17 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.99.17 |
EC number:2.4.99.17
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:32155 | 7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH2;+0:6]-[*:7]-[O;H0;+0:8]-[CH;+0:9](-[*:10])-[n;H0;+0:11](:[*:12]):[*:13]>>[*:1]-[NH;+0:2]-[CH;+0:9](-[*:10])-[CH;+0:6]1-[*:7]-[O;H0;+0:8]-1.[*:3]-[S;H0;+0:4]-[*:5].[*:12]:[nH;+0:11]:[*:13] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A new function of S-adenosylmethionine: the ribosyl moiety of AdoMet is the precursor of the cyclopentenediol moiety of the tRNA wobble base queuine. | Slany RK, Bösl M, Crain PF, Kersten H | 1993 Aug 3 | 8347586 |
| Transfer and isomerization of the ribose moiety of AdoMet during the biosynthesis of queuosine tRNAs, a new unique reaction catalyzed by the QueA protein from Escherichia coli. | Slany RK, Bösl M, Kersten H | 1994 | 7849103 |
| Kinetic mechanism of the tRNA-modifying enzyme S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA). | Van Lanen SG, Iwata-Reuyl D | 2003 May 13 | 12731872 |
| Mechanistic studies of the tRNA-modifying enzyme QueA: a chemical imperative for the use of AdoMet as a "ribosyl" donor. | Kinzie SD, Thern B, Iwata-Reuyl D | 2000 May 4 | 10810734 |