EC number:2.4.99.2
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.4 Glycosyltransferases |
| 2.4.99 Transferring other glycosyl groups |
| ID: | 2.4.99.2 |
|---|---|
| Description: | sialyltransferase. |
| Alternative Name: |
Monosialoganglioside sialyltransferase. |
| Cath: | 3.90.1480.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.99.2 |
| BRENDA Enzyme Link: | BRENDA 2.4.99.2 |
| KEGG Enzyme Link: | KEGG2.4.99.2 |
| BioCyc Enzyme Link: | BioCyc 2.4.99.2 |
| ExPASy Enzyme Link: | ExPASy2.4.99.2 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.99.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.99.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.99.2 |
| IntEnz Enzyme Link: | IntEnz 2.4.99.2 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.99.2 |
| RHEA:52380 | a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:8]-[*:7].[*:6]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line. | Giordanengo V, Bannwarth S, Laffont C, Van Miegem V, Harduin-Lepers A, Delannoy P, Lefebvre JC | 1997 Jul 15 | 9266697 |
| Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II). | Kim YJ, Kim KS, Kim SH, Kim CH, Ko JH, Choe IS, Tsuji S, Lee YC | 1996 Nov 12 | 8920913 |
| Molecular cloning and expression of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase from mouse brain. | Lee YC, Kurosawa N, Hamamoto T, Nakaoka T, Tsuji S | 1993 Sep 1 | 8375377 |
| Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. | Kitagawa H, Paulson JC | 1994 Jan 14 | 8288606 |
| Kinetic properties and acceptor substrate preferences of two kinds of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase from mouse brain. | Kojima N, Lee YC, Hamamoto T, Kurosawa N, Tsuji S | 1994 May 17 | 8180204 |
| Enzymatic characterization of beta D-galactoside alpha2 leads to 3 sialyltransferase from porcine submaxillary gland. | Rearick JI, Sadler JE, Paulson JC, Hill RL | 1979 Jun 10 | 438198 |
| The enzymic synthesis of disialoganglioside: rat brain cytidine-5'-monophospho-N-acetylneuraminic acid: monosialoganglioside (G M1 ) sialyltransferase. | Yip MC | 1973 May 24 | 4351506 |
| RHEA:18021 | CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (18:1(4E)) + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:8]-[*:7].[*:6]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line. | Giordanengo V, Bannwarth S, Laffont C, Van Miegem V, Harduin-Lepers A, Delannoy P, Lefebvre JC | 1997 Jul 15 | 9266697 |
| Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II). | Kim YJ, Kim KS, Kim SH, Kim CH, Ko JH, Choe IS, Tsuji S, Lee YC | 1996 Nov 12 | 8920913 |
| Molecular cloning and expression of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase from mouse brain. | Lee YC, Kurosawa N, Hamamoto T, Nakaoka T, Tsuji S | 1993 Sep 1 | 8375377 |
| Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. | Kitagawa H, Paulson JC | 1994 Jan 14 | 8288606 |
| Kinetic properties and acceptor substrate preferences of two kinds of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase from mouse brain. | Kojima N, Lee YC, Hamamoto T, Kurosawa N, Tsuji S | 1994 May 17 | 8180204 |
| Enzymatic characterization of beta D-galactoside alpha2 leads to 3 sialyltransferase from porcine submaxillary gland. | Rearick JI, Sadler JE, Paulson JC, Hill RL | 1979 Jun 10 | 438198 |
| The enzymic synthesis of disialoganglioside: rat brain cytidine-5'-monophospho-N-acetylneuraminic acid: monosialoganglioside (G M1 ) sialyltransferase. | Yip MC | 1973 May 24 | 4351506 |