EC number:2.4.99.4
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.4 Glycosyltransferases |
| 2.4.99 Transferring other glycosyl groups |
| ID: | 2.4.99.4 |
|---|---|
| Description: | Beta-galactoside alpha-2,3-sialyltransferase. |
| Alternative Name: |
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase. |
| Cath: | 3.90.1480.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.99.4 |
| BRENDA Enzyme Link: | BRENDA 2.4.99.4 |
| KEGG Enzyme Link: | KEGG2.4.99.4 |
| BioCyc Enzyme Link: | BioCyc 2.4.99.4 |
| ExPASy Enzyme Link: | ExPASy2.4.99.4 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.99.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.99.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.99.4 |
| IntEnz Enzyme Link: | IntEnz 2.4.99.4 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.99.4 |
| RHEA:21616 | a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:8]-[*:7].[*:6]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymatic characterization of beta D-galactoside alpha2 leads to 3 sialyltransferase from porcine submaxillary gland. | Rearick JI, Sadler JE, Paulson JC, Hill RL | 1979 Jun 10 | 438198 |
| Purification to homogeneity of a beta-galactoside alpha2 leads to 3 sialyltransferase and partial purification of an alpha-N-acetylgalactosaminide alpha2 leads to 6 sialyltransferase from porcine submaxillary glands. | Sadler JE, Rearick JI, Paulson JC, Hill RL | 1979 Jun 10 | 438196 |
| Structural insight into mammalian sialyltransferases. | Rao FV, Rich JR, Rakić B, Buddai S, Schwartz MF, Johnson K, Bowe C, Wakarchuk WW, Defrees S, Withers SG, Strynadka NC | 2009 Nov | 19820709 |