EC number:2.4.99.6
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.4 Glycosyltransferases |
| 2.4.99 Transferring other glycosyl groups |
| ID: | 2.4.99.6 |
|---|---|
| Description: | N-acetyllactosaminide alpha-2,3-sialyltransferase. |
| Alternative Name: |
Neolactotetraosylceramide alpha-2,3-sialyltransferase. |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.99.6 |
| BRENDA Enzyme Link: | BRENDA 2.4.99.6 |
| KEGG Enzyme Link: | KEGG2.4.99.6 |
| BioCyc Enzyme Link: | BioCyc 2.4.99.6 |
| ExPASy Enzyme Link: | ExPASy2.4.99.6 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.99.6 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.99.6 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.99.6 |
| IntEnz Enzyme Link: | IntEnz 2.4.99.6 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.99.6 |
| RHEA:52316 | a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:8]-[*:7].[*:6]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Detection of beta-galactosyl(1 leads to 4)N-acetylglucosaminide alpha(2 leads to 3)-sialyltransferase activity in fetal calf liver and other tissues. | Van den Eijnden DH, Schiphorst WE | 1981 Apr 10 | 7204397 |
| Synthesis of bisubstrate and donor analogues of sialyltransferase and their inhibitory activities. | Izumi M, Wada K, Yuasa H, Hashimoto H | 2005 Oct 28 | 16238314 |
| Biosynthesis in vitro of sialyl(alpha 2-3)neolactotetraosylceramide by a sialyltransferase from embryonic chicken brain. | Basu M, Basu S, Stoffyn A, Stoffyn P | 1982 Nov 10 | 7130178 |
| Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. | Kono M, Ohyama Y, Lee YC, Hamamoto T, Kojima N, Tsuji S | 1997 Jun | 9184827 |
| RHEA:18913 | beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:8]-[*:7].[*:6]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biosynthesis in vitro of sialyl(alpha 2-3)neolactotetraosylceramide by a sialyltransferase from embryonic chicken brain. | Basu M, Basu S, Stoffyn A, Stoffyn P | 1982 Nov 10 | 7130178 |