EC number:2.4.99.7
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.4 Glycosyltransferases |
| 2.4.99 Transferring other glycosyl groups |
| ID: | 2.4.99.7 |
|---|---|
| Description: | 6-alpha-sialyltransferase. |
| Alternative Name: |
ST6GALNAC. Sialyltransferase 7D. Sialyltransferase 3C. Sialyltransferase. NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase. galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase. Cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta- alpha-2,6-sialyltransferase. Alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.99.7 |
| BRENDA Enzyme Link: | BRENDA 2.4.99.7 |
| KEGG Enzyme Link: | KEGG2.4.99.7 |
| BioCyc Enzyme Link: | BioCyc 2.4.99.7 |
| ExPASy Enzyme Link: | ExPASy2.4.99.7 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.99.7 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.99.7 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.99.7 |
| IntEnz Enzyme Link: | IntEnz 2.4.99.7 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.99.7 |
| RHEA:53896 | an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:8]-[*:7].[*:6]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biosynthesis of the O-glycosidically linked oligosaccharide chains of fetuin. Indications for an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase with a narrow acceptor specificity in fetal calf liver. | Bergh ML, Hooghwinkel GJ, van den Eijnden DH | 1983 Jun 25 | 6190802 |
| Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV. | Lee YC, Kaufmann M, Kitazume-Kawaguchi S, Kono M, Takashima S, Kurosawa N, Liu H, Pircher H, Tsuji S | 1999 Apr 23 | 10207017 |
| Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. | Senda M, Ito A, Tsuchida A, Hagiwara T, Kaneda T, Nakamura Y, Kasama K, Kiso M, Yoshikawa K, Katagiri Y, Ono Y, Ogiso M, Urano T, Furukawa K, Oshima S, Furukawa K | 2007 Mar 15 | 17123352 |
| Molecular cloning and expression of human ST6GalNAc III: restricted tissue distribution and substrate specificity. | Tsuchida A, Ogiso M, Nakamura Y, Kiso M, Furukawa K, Furukawa K | 2005 Sep | 16169874 |