EC number:2.4.99.8
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.4 Glycosyltransferases |
| 2.4.99 Transferring other glycosyl groups |
| ID: | 2.4.99.8 |
|---|---|
| Description: | Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase. |
| Alternative Name: |
Alpha-2,8-sialyltransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.99.8 |
| BRENDA Enzyme Link: | BRENDA 2.4.99.8 |
| KEGG Enzyme Link: | KEGG2.4.99.8 |
| BioCyc Enzyme Link: | BioCyc 2.4.99.8 |
| ExPASy Enzyme Link: | ExPASy2.4.99.8 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.99.8 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.99.8 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.99.8 |
| IntEnz Enzyme Link: | IntEnz 2.4.99.8 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.99.8 |
| RHEA:19313 | an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:8]-[*:7].[*:6]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme. | Nakayama J, Fukuda MN, Hirabayashi Y, Kanamori A, Sasaki K, Nishi T, Fukuda M | 1996 Feb 16 | 8631981 |
| Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase). | Sasaki K, Kurata K, Kojima N, Kurosawa N, Ohta S, Hanai N, Tsuji S, Nishi T | 1994 Jun 3 | 8195250 |
| Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells. | Nara K, Watanabe Y, Maruyama K, Kasahara K, Nagai Y, Sanai Y | 1994 Aug 16 | 8058740 |
| Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody. | Haraguchi M, Yamashiro S, Yamamoto A, Furukawa K, Takamiya K, Lloyd KO, Shiku H, Furukawa K | 1994 Oct 25 | 7937974 |