EC number:2.4.99.9
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.4 Glycosyltransferases |
| 2.4.99 Transferring other glycosyl groups |
| ID: | 2.4.99.9 |
|---|---|
| Description: | Lactosylceramide alpha-2,3-sialyltransferase. |
| Alternative Name: |
Ganglioside GM3 synthase. |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.4.99.9 |
| BRENDA Enzyme Link: | BRENDA 2.4.99.9 |
| KEGG Enzyme Link: | KEGG2.4.99.9 |
| BioCyc Enzyme Link: | BioCyc 2.4.99.9 |
| ExPASy Enzyme Link: | ExPASy2.4.99.9 |
| EC2PDB Enzyme Link: | EC2PDB 2.4.99.9 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.4.99.9 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.4.99.9 |
| IntEnz Enzyme Link: | IntEnz 2.4.99.9 |
| MEDLINE Enzyme Link: | MEDLINE 2.4.99.9 |
| RHEA:18417 | beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + ganglioside GM3 (d18:1(4E)) + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[OH;+0:8]>>[*:7]-[O;H0;+0:8]-[C;H0;+0:2](-[*:1])(-[*:3])-[*:4].[*:6]-[OH;+0:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase. | Ishii A, Ohta M, Watanabe Y, Matsuda K, Ishiyama K, Sakoe K, Nakamura M, Inokuchi J, Sanai Y, Saito M | 1998 Nov 27 | 9822625 |
| Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain. | Higashi H, Basu M, Basu S | 1985 Jan 25 | 3838172 |
| Human GM3 synthase: a new mRNA variant encodes an NH2-terminal extended form of the protein. | Berselli P, Zava S, Sottocornola E, Milani S, Berra B, Colombo I | 2006 Jul | 16934889 |
| Expression cloning of mouse cDNA of CMP-NeuAc:Lactosylceramide alpha2,3-sialyltransferase, an enzyme that initiates the synthesis of gangliosides. | Fukumoto S, Miyazaki H, Goto G, Urano T, Furukawa K, Furukawa K | 1999 Apr 2 | 10092602 |