EnzyMine

Download

EC Tree

2. Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

ID:	2.5.1.114
Description:	tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase.
Alternative Name:	tRNA-yW synthesizing enzyme-2.
Cath:	3.30.300.110; 3.40.50.150;

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

PDB	Click once to unfold,double click to fold.

UniProtKB Enzyme Link:	UniProtKB 2.5.1.114
BRENDA Enzyme Link:	BRENDA 2.5.1.114
KEGG Enzyme Link:	KEGG2.5.1.114
BioCyc Enzyme Link:	BioCyc 2.5.1.114
ExPASy Enzyme Link:	ExPASy2.5.1.114
EC2PDB Enzyme Link:	EC2PDB 2.5.1.114
ExplorEnz Enzyme Link:	ExplorEnz 2.5.1.114
PRIAM enzyme-specific profiles Link:	PRIAM 2.5.1.114
IntEnz Enzyme Link:	IntEnz 2.5.1.114
MEDLINE Enzyme Link:	MEDLINE 2.5.1.114

RHEA:36355	4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine
RULE(radius=1)	[:1]-[CH2;+0:2]-[S+;H0:3](-[:4])-[:5].[:6]:[n;H0;+0:7]:[:8]1:[:9]:[cH;+0:10]:[:11]:[nH;+0:12]:1>>[:4]-[S;H0;+0:3]-[:5].[:6]:[nH;+0:7]:[:8]1:[:9]:[c;H0;+0:10](-[CH2;+0:2]-[:1]):[:11]:[n;H0;+0:12]:1
Reaction
Core-to-Core	More

Title	Authors	Date	PubMed ID
Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA.	Rodriguez V, Vasudevan S, Noma A, Carlson BA, Green JE, Suzuki T, Chandrasekharappa SC	2012	22761755
Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2.	Umitsu M, Nishimasu H, Noma A, Suzuki T, Ishitani R, Nureki O	2009 Sep 15	19717466