EC number:2.5.1.137

Enzyme

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     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.137
Description:2-acyl-4-prenylphloroglucinol 6-prenyltransferase.
Alternative Name: Aromatic prenyltransferase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.137
BRENDA Enzyme Link: BRENDA 2.5.1.137
KEGG Enzyme Link: KEGG2.5.1.137
BioCyc Enzyme Link: BioCyc 2.5.1.137
ExPASy Enzyme Link: ExPASy2.5.1.137
EC2PDB Enzyme Link: EC2PDB 2.5.1.137
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.137
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.137
IntEnz Enzyme Link: IntEnz 2.5.1.137
MEDLINE Enzyme Link: MEDLINE 2.5.1.137

EC number:2.5.1.137

MSA:

2.5.1.137;
Phylogenetic Tree:

2.5.1.137;
Uniprot:
M-CSA:
RHEA:51756 a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6-diprenylphloroglucinol + diphosphate
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH2;+0:3]-[*:4].[*:5]:[cH;+0:6]:[*:7]>>[*:4]-[CH2;+0:3]-[c;H0;+0:6](:[*:5]):[*:7].[*:1]-[OH;+0:2]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway.Li H, Ban Z, Qin H, Ma L, King AJ, Wang G2015 Mar25564559
RHEA:51760 a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[c;H0;+0:6]1:[c;H0;+0:7](-[OH;+0:8]):[c;H0;+0:9](-[*:10]):[c;H0;+0:11](-[*:12]):[c;H0;+0:13](-[*:14]):[c;H0;+0:15]:1-[*:16]>>[*:5]-[C;H0;+0:6]1(-[CH2;+0:3]-[*:4])-[C;H0;+0:7](=[O;H0;+0:8])-[C;H0;+0:9](-[*:10])=[C;H0;+0:11](-[*:12])-[C;H0;+0:13](-[*:14])=[C;H0;+0:15]-1-[*:16].[*:1]-[OH;+0:2]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway.Li H, Ban Z, Qin H, Ma L, King AJ, Wang G2015 Mar25564559
RHEA:51776 4-prenylphlorisobutanophenone + dimethylallyl diphosphate = deoxycohumulone + diphosphate
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH2;+0:3]-[*:4].[*:5]:[cH;+0:6]:[*:7]>>[*:4]-[CH2;+0:3]-[c;H0;+0:6](:[*:5]):[*:7].[*:1]-[OH;+0:2]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway.Li H, Ban Z, Qin H, Ma L, King AJ, Wang G2015 Mar25564559
RHEA:51780 4-prenylphlormethylbutanophenone + dimethylallyl diphosphate = deoxyadlupulone + diphosphate
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH2;+0:3]-[*:4].[*:5]:[cH;+0:6]:[*:7]>>[*:4]-[CH2;+0:3]-[c;H0;+0:6](:[*:5]):[*:7].[*:1]-[OH;+0:2]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway.Li H, Ban Z, Qin H, Ma L, King AJ, Wang G2015 Mar25564559
RHEA:51784 4-prenylphlorisovalerophenone + dimethylallyl diphosphate = deoxyhumulone + diphosphate
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH2;+0:3]-[*:4].[*:5]:[cH;+0:6]:[*:7]>>[*:4]-[CH2;+0:3]-[c;H0;+0:6](:[*:5]):[*:7].[*:1]-[OH;+0:2]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway.Li H, Ban Z, Qin H, Ma L, King AJ, Wang G2015 Mar25564559
RHEA:51796 deoxycohumulone + dimethylallyl diphosphate = colupulone + diphosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[c;H0;+0:6]1:[c;H0;+0:7](-[OH;+0:8]):[c;H0;+0:9](-[*:10]):[c;H0;+0:11](-[*:12]):[c;H0;+0:13](-[*:14]):[c;H0;+0:15]:1-[*:16]>>[*:5]-[C;H0;+0:6]1(-[CH2;+0:3]-[*:4])-[C;H0;+0:7](=[O;H0;+0:8])-[C;H0;+0:9](-[*:10])=[C;H0;+0:11](-[*:12])-[C;H0;+0:13](-[*:14])=[C;H0;+0:15]-1-[*:16].[*:1]-[OH;+0:2]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway.Li H, Ban Z, Qin H, Ma L, King AJ, Wang G2015 Mar25564559
RHEA:51800 deoxyadlupulone + dimethylallyl diphosphate = adlupulone + diphosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[c;H0;+0:6]1:[c;H0;+0:7](-[OH;+0:8]):[c;H0;+0:9](-[*:10]):[c;H0;+0:11](-[*:12]):[c;H0;+0:13](-[*:14]):[c;H0;+0:15]:1-[*:16]>>[*:5]-[C;H0;+0:6]1(-[CH2;+0:3]-[*:4])-[C;H0;+0:7](=[O;H0;+0:8])-[C;H0;+0:9](-[*:10])=[C;H0;+0:11](-[*:12])-[C;H0;+0:13](-[*:14])=[C;H0;+0:15]-1-[*:16].[*:1]-[OH;+0:2]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway.Li H, Ban Z, Qin H, Ma L, King AJ, Wang G2015 Mar25564559
RHEA:51804 deoxyhumulone + dimethylallyl diphosphate = diphosphate + H(+) + lupulone
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[c;H0;+0:6]1:[c;H0;+0:7](-[*:8]):[c;H0;+0:9](-[OH;+0:10]):[c;H0;+0:11](-[*:12]):[c;H0;+0:13](-[*:14]):[c;H0;+0:15]:1-[*:16]>>[*:5]-[C;H0;+0:6]1=[C;H0;+0:7](-[*:8])-[C;H0;+0:9](=[O;H0;+0:10])-[C;H0;+0:11](-[*:12])(-[CH2;+0:3]-[*:4])-[C;H0;+0:13](-[*:14])=[C;H0;+0:15]-1-[*:16].[*:1]-[OH;+0:2]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway.Li H, Ban Z, Qin H, Ma L, King AJ, Wang G2015 Mar25564559