EC number:2.5.1.143

Enzyme

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     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.143
Description:Pyridinium-3,5-biscarboxylic acid mononucleotide synthase.
Alternative Name: P2CMN synthase.
Nicotinic acid adenine dinucleotide carboxylase/hydrolase.
NaAD carboxylase/hydrolase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.143
BRENDA Enzyme Link: BRENDA 2.5.1.143
KEGG Enzyme Link: KEGG2.5.1.143
BioCyc Enzyme Link: BioCyc 2.5.1.143
ExPASy Enzyme Link: ExPASy2.5.1.143
EC2PDB Enzyme Link: EC2PDB 2.5.1.143
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.143
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.143
IntEnz Enzyme Link: IntEnz 2.5.1.143
MEDLINE Enzyme Link: MEDLINE 2.5.1.143

EC number:2.5.1.143

MSA:

2.5.1.143;
Phylogenetic Tree:

2.5.1.143;
Uniprot:
M-CSA:
RHEA:54756 deamido-NAD(+) + hydrogencarbonate = AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide
RULE(radius=1) ([*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]:[cH;+0:8]:[*:9]).[*:10]=[C;H0;+0:11](-[*:12])-[OH;+0:13]>>[*:6]-[OH;+0:5].([*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:13].[*:10]=[C;H0;+0:11](-[*:12])-[c;H0;+0:8](:[*:7]):[*:9])
Reaction
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References

TitleAuthorsDatePubMed ID
Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.Desguin B, Soumillion P, Hols P, Hausinger RP2016 May 1727114550