EC number:2.5.1.17
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.5 Transferring alkyl or aryl groups, other than methyl groups |
| 2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| ID: | 2.5.1.17 |
|---|---|
| Description: | Corrinoid adenosyltransferase. |
| Alternative Name: |
Cob(I)yrinic acid a,c-diamide adenosyltransferase. Cob(I)alamin adenosyltransferase. ATP:corrinoid adenosyltransferase. ATP:cob(I)alamin Co-beta-adenosyltransferase. Aquocob(I)alamin vitamin B12s adenosyltransferase. Aquacob(I)alamin adenosyltransferase. |
| Cath: | 1.20.1200.10; 3.40.50.300; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.5.1.17 |
| BRENDA Enzyme Link: | BRENDA 2.5.1.17 |
| KEGG Enzyme Link: | KEGG2.5.1.17 |
| BioCyc Enzyme Link: | BioCyc 2.5.1.17 |
| ExPASy Enzyme Link: | ExPASy2.5.1.17 |
| EC2PDB Enzyme Link: | EC2PDB 2.5.1.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.5.1.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.5.1.17 |
| IntEnz Enzyme Link: | IntEnz 2.5.1.17 |
| MEDLINE Enzyme Link: | MEDLINE 2.5.1.17 |
| RHEA:14725 | 2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]-[O;H0;+0:12]-[CH2;+0:13]-[*:14].[*:15]-[O;H0;+0:16]-[CH2;+0:17]-[*:18]>>[*:14]-[CH2;+0:13].[*:18]-[CH2;+0:17].[*:11]-[OH;+0:12].[*:15]-[OH;+0:16].[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and initial characterization of the ATP:corrinoid adenosyltransferase encoded by the cobA gene of Salmonella typhimurium. | Suh S, Escalante-Semerena JC | 1995 Feb | 7860601 |
| Enzymatic conversion of vitamin B-12s to a cobamide coenzyme, alpha-(5,6-dimethylbenzimidazolyl)deoxyadenosylcobamide (adenosyl-B-12). | Vitols E, Walker GA, Huennekens FM | 1966 Apr 10 | 5946606 |
| An in vitro reducing system for the enzymic conversion of cobalamin to adenosylcobalamin. | Fonseca MV, Escalante-Semerena JC | 2001 Aug 24 | 11408479 |
| Three-dimensional structure of ATP:corrinoid adenosyltransferase from Salmonella typhimurium in its free state, complexed with MgATP, or complexed with hydroxycobalamin and MgATP. | Bauer CB, Fonseca MV, Holden HM, Thoden JB, Thompson TB, Escalante-Semerena JC, Rayment I | 2001 Jan 16 | 11148030 |
| RHEA:11528 | 2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[O;H0;+0:6]-[CH2;+0:7]-[*:8].[*:9]:[nH;+0:10]:[c;H0;+0:11]1:[c;H0;+0:12](:[*:13])-[NH;+0:14]-[*:15]:[*:16]-[N;H0;+0:17]-1-[*:18].[*:19]=[N+;H0:20](-[*:21])-[Co-2;H0:22](-[*:23])(-[N+;H0:24](-[*:25])=[*:26])-[N+;H0:27](-[*:28])=[*:29].[*:30]=[N+;H0:31](-[*:32])-[Co-2;H0:33](-[*:34])(-[N+;H0:35](-[*:36])=[*:37])-[N+;H0:38](-[*:39])=[*:40]>>([*:8]-[CH2;+0:7]-[Co+;H0:33]-[*:34].[*:36]-[N;H0;+0:35]=[*:37].[*:39]-[N;H0;+0:38]=[*:40].[*:30]=[N;H0;+0:31]-[*:32]).([*:23]-[Co+;H0:22]-[CH2;+0:3]-[*:4].[*:25]-[N;H0;+0:24]=[*:26].[*:28]-[N;H0;+0:27]=[*:29].[*:19]=[N;H0;+0:20]-[*:21]).[*:1]-[OH;+0:2].[*:5]-[OH;+0:6].[*:9]:[n;H0;+0:10]:[c;H0;+0:11]1:[n;H0;+0:17](-[*:18]):[*:16]:[*:15]:[n;H0;+0:14]:[c;H0;+0:12]-1:[*:13] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Dihydroflavin-driven adenosylation of 4-coordinate Co(II) corrinoids: are cobalamin reductases enzymes or electron transfer proteins? | Mera PE, Escalante-Semerena JC | 2010 Jan 29 | 19933577 |
| Residue Phe112 of the human-type corrinoid adenosyltransferase (PduO) enzyme of Lactobacillus reuteri is critical to the formation of the four-coordinate Co(II) corrinoid substrate and to the activity of the enzyme. | Mera PE, St Maurice M, Rayment I, Escalante-Semerena JC | 2009 Apr 14 | 19236001 |
| Reduction of Cob(III)alamin to Cob(II)alamin in Salmonella enterica serovar typhimurium LT2. | Fonseca MV, Escalante-Semerena JC | 2000 Aug | 10894741 |
| Purification and initial characterization of the ATP:corrinoid adenosyltransferase encoded by the cobA gene of Salmonella typhimurium. | Suh S, Escalante-Semerena JC | 1995 Feb | 7860601 |
| Enzymatic conversion of vitamin B-12s to a cobamide coenzyme, alpha-(5,6-dimethylbenzimidazolyl)deoxyadenosylcobamide (adenosyl-B-12). | Vitols E, Walker GA, Huennekens FM | 1966 Apr 10 | 5946606 |
| An in vitro reducing system for the enzymic conversion of cobalamin to adenosylcobalamin. | Fonseca MV, Escalante-Semerena JC | 2001 Aug 24 | 11408479 |
| Three-dimensional structure of ATP:corrinoid adenosyltransferase from Salmonella typhimurium in its free state, complexed with MgATP, or complexed with hydroxycobalamin and MgATP. | Bauer CB, Fonseca MV, Holden HM, Thoden JB, Thompson TB, Escalante-Semerena JC, Rayment I | 2001 Jan 16 | 11148030 |