EC number:2.5.1.2

Enzyme

Download
EC Tree
     2. Transferases
        2.5 Transferring alkyl or aryl groups, other than methyl groups
            2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
ID:2.5.1.2
Description:Thiamine pyridinylase.
Alternative Name: Thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase.
Thiamine pyridinolase.
Thiamine hydrolase.
Thiaminase I.
Thiaminase.
Pyrimidine transferase.
Cath: 3.40.190.10;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.5.1.2
BRENDA Enzyme Link: BRENDA 2.5.1.2
KEGG Enzyme Link: KEGG2.5.1.2
BioCyc Enzyme Link: BioCyc 2.5.1.2
ExPASy Enzyme Link: ExPASy2.5.1.2
EC2PDB Enzyme Link: EC2PDB 2.5.1.2
ExplorEnz Enzyme Link: ExplorEnz 2.5.1.2
PRIAM enzyme-specific profiles Link: PRIAM 2.5.1.2
IntEnz Enzyme Link: IntEnz 2.5.1.2
MEDLINE Enzyme Link: MEDLINE 2.5.1.2

EC number:2.5.1.2

MSA:

2.5.1.2;
Phylogenetic Tree:

2.5.1.2;
Uniprot:
M-CSA:
RHEA:17697 pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine
RULE(radius=1) [*:1]-[CH2;+0:2]-[n+;H0:3](:[*:4]):[*:5].[*:6]:[n;H0;+0:7]:[*:8]>>[*:1]-[CH2;+0:2]-[n+;H0:7](:[*:6]):[*:8].[*:4]:[n;H0;+0:3]:[*:5]
Reaction
Core-to-Core More
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Crystal structure of thiaminase-I from Bacillus thiaminolyticus at 2.0 A resolution.Campobasso N, Costello CA, Kinsland C, Begley TP, Ealick SE1998 Nov 109843405
The extracellular thiaminase I of Bacillus thiaminolyticus. I. Purification and physicochemical properties.Wittliff JL, Airth RL1968 Feb4966932