EC number:2.7.1.160
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.1 Phosphotransferases with an alcohol group as acceptor |
| ID: | 2.7.1.160 |
|---|---|
| Description: | 2'-phosphotransferase. |
| Alternative Name: |
Yeast 2'-phosphotransferase. Tpt1p. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.1.160 |
| BRENDA Enzyme Link: | BRENDA 2.7.1.160 |
| KEGG Enzyme Link: | KEGG2.7.1.160 |
| BioCyc Enzyme Link: | BioCyc 2.7.1.160 |
| ExPASy Enzyme Link: | ExPASy2.7.1.160 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.1.160 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.1.160 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.1.160 |
| IntEnz Enzyme Link: | IntEnz 2.7.1.160 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.1.160 |
EC number:2.7.1.160
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:23324 | 2'-phospho-[ligated tRNA] + NAD(+) = ADP-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3]-[OH;+0:4])-[n+;H0:5](:[*:6]):[*:7].[*:8]-[O;H0;+0:9]-[P;H0;+0:10](=[*:11])(-[*:12])-[OH;+0:13]>>[*:1]-[CH;+0:2]1-[*:3]-[O;H0;+0:4]-[P;H0;+0:10](=[*:11])(-[*:12])-[O;H0;+0:13]-1.[*:8]-[OH;+0:9].[*:6]:[n;H0;+0:5]:[*:7] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Transient ADP-ribosylation of a 2'-phosphate implicated in its removal from ligated tRNA during splicing in yeast. | Spinelli SL, Kierzek R, Turner DH, Phizicky EM | 1999 Jan 29 | 9915792 |
| Analysis of 2'-phosphotransferase (Tpt1p) from Saccharomyces cerevisiae: evidence for a conserved two-step reaction mechanism. | Steiger MA, Jackman JE, Phizicky EM | 2005 Jan | 15611300 |
| A human homolog of the yeast gene encoding tRNA 2'-phosphotransferase: cloning, characterization and complementation analysis. | Hu QD, Lu H, Huo K, Ying K, Li J, Xie Y, Mao Y, Li YY | 2003 Aug | 14504659 |
| Substrate recognition by a yeast 2'-phosphotransferase involved in tRNA splicing and by its Escherichia coli homolog. | Steiger MA, Kierzek R, Turner DH, Phizicky EM | 2001 Nov 20 | 11705403 |