EC number:2.7.7.49

Enzyme

Download
EC Tree
     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.7 Nucleotidyltransferases
ID:2.7.7.49
Description:RNA-directed DNA polymerase.
Alternative Name: Revertase.
Reverse transcriptase.
DNA nucleotidyltransferase (RNA-directed).
Prosite: PDOC50878;
PDB:
PDBScop
1N5Y 8091538; 8091539; 8075087; 8075088;
3KLF 8075087; 8075088; 8075087; 8075088; 8075087; 8075088; 8075087; 8075088;
3KLE 8075087; 8075088; 8075087; 8075088; 8075087; 8075088; 8075087; 8075088;
1HVU 8075087; 8075088; 8075087; 8075088; 8075087; 8075088; 8075087; 8075088;
1HMV 8075087; 8075088; 8075087; 8075088; 8075087; 8075088; 8075087; 8075088;
 » show all
Cath: 1.10.10.10; 1.10.10.1010; 1.10.10.160; 1.10.10.1600; 1.10.10.1970; 1.10.10.200; 1.10.10.2300; 1.10.100.20; 1.10.1200.30; 1.10.132.60;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

Click once to unfold,double click to fold.
1N5Y; 3KLF; 3KLE; 1HVU; 1HMV; 6HAK; 6AVT; 6AVM; 6ASW; 6AOC; 6ANQ; 6AN8; 6AN2; 6AMO; 5UV5; 5TXP; 5TXO; 5TXN; 5TXM; 5TXL; 5J1E; 5I42; 5I3U; 5HRO; 5HP1; 5HLF; 5D3G; 4R5P; 4Q0B; 4PWD; 4PUO; 4PQU; 3V81; 3V6D; 3V4I; 3KLG; 3ITH; 1T05; 6OE3; 6ELI; 6DUH; 6DUG; 6DUF; 6CGF; 6C0R; 6C0P; 6C0O; 6C0N; 6C0L; 6C0K; 6C0J; 6B19; 5VQZ; 5VQY; 5VQX; 5VQV; 5VQT; 5VQS; 5VQR; 5VQQ; 5TW3; 5TUQ; 5TER; 5TEP; 5HBM; 5FDL; 5CYQ; 5CYM; 5C42; 5C25; 5C24; 4WE1; 4RW9; 4RW8; 4RW7; 4RW6; 4RW4; 4O4G; 4O44; 4MFB; 4LSN; 4LSL; 4KO0; 4KKO; 4KFB; 4IG3; 4IG0; 4IFY; 4IFV; 4IDK; 4ID5; 4ICL; 4I2Q; 4I2P; 4H4O; 4H4M; 4G1Q; 4DG1; 3QO9; 3QLH; 3KLI; 3KLH; 3JYT; 3ISN; 3IS9; 3IRX; 3IG1; 3HVT; 3DLK; 2ZE2; 2ZD1; 2YKN; 2YKM; 2VG7; 2VG6; 2VG5; 2IC3; 2IAJ; 2I5J; 2HMI; 2BE2; 2BAN; 2B6A; 2B5J; 1UWB; 1TVR; 1TV6; 1T03; 1SV5; 1SUQ; 1S9G; 1S9E; 1S6Q; 1S6P; 1R0A; 1QE1; 1N6Q; 1J5O; 1IKY; 1IKX; 1IKW; 1IKV; 1HYS; 1HQU; 1HQE; 1HPZ; 1HNV; 1HNI; 1EET; 1DLO; 1BQN; 1BQM; 6D6V; 1MU2; 1RTD; 6BSJ; 6BSI; 5J2P; 4NCG; 4I7F; 3T19; 3MED; 3M8Q; 3LP2; 3I0R; 3E01; 3DYA; 2YNI; 2YNH; 2WON; 2RF2; 2OPP; 1TL1; 1S1X; 1RTI; 1RT6; 1RT1; 1LWF; 1JLF; 1JLA; 1FKO; 1DTT; 1C1B; 1C0U; 4KSE; 3DOK; 6BSH; 6BSG; 5J2Q; 5J2N; 5J2M; 4KV8; 4B3Q; 4B3P; 4B3O; 3TAM; 3T1A; 3QIP; 3NBP; 3MEG; 3MEE; 3MEC; 3M8P; 3LP1; 3LP0; 3LAN; 3LAM; 3LAK; 3KK3; 3KK2; 3KK1; 3KJV; 3I0S; 3DRS; 3DRR; 3DRP; 3DLG; 3DLE; 3DI6; 3C6U; 3C6T; 2YNG; 2YNF; 2WOM; 2RKI; 2OPS; 2OPR; 2OPQ; 2HNZ; 1VRU; 1VRT; 1TL3; 1TKZ; 1TKX; 1TKT; 1S1W; 1S1V; 1S1U; 1S1T; 1RTJ; 1RTH; 1RT7; 1RT5; 1RT4; 1RT3; 1RT2; 1REV; 1LWE; 1LWC; 1LW2; 1LW0; 1KLM; 1JLQ; 1JLG; 1JLE; 1JLC; 1JLB; 1JKH; 1FKP; 1FK9; 1EP4; 1DTQ; 1C1C; 1C0T; 5K14; 2HNY; 2HND; 5DMQ; 6B1S; 1QAJ; 1QAI; 1D0E; 6MIK; 6MIH; 6MIG; 6B1R; 6B1Q; 5VBS; 4XPE; 4XPC; 4XO0; 4MH8; 4M95; 4M94; 3FSI; 2R2U; 2R2T; 2R2S; 2R2R; 2FVS; 2FVR; 2FVQ; 2FVP; 2FJX; 2FJW; 2FJV; 1ZTW; 1ZTT; 1NND; 1N4L; 1MML; 1D1U; 3BGR; 6IKA; 6IK9; 5XN2; 5XN1; 5XN0; 5VZ6; 5VQW; 5VQU; 5G2X; 4ZHR; 4OL8; 4HKQ; 3LAL; 3JSM; 3FFI; 3DOL; 3DMJ; 3DM2; 1I6J; 1HAR;

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.7.49
BRENDA Enzyme Link: BRENDA 2.7.7.49
KEGG Enzyme Link: KEGG2.7.7.49
BioCyc Enzyme Link: BioCyc 2.7.7.49
ExPASy Enzyme Link: ExPASy2.7.7.49
EC2PDB Enzyme Link: EC2PDB 2.7.7.49
ExplorEnz Enzyme Link: ExplorEnz 2.7.7.49
PRIAM enzyme-specific profiles Link: PRIAM 2.7.7.49
IntEnz Enzyme Link: IntEnz 2.7.7.49
MEDLINE Enzyme Link: MEDLINE 2.7.7.49

EC number:2.7.7.49

MSA:

2.7.7.49;
Phylogenetic Tree:

2.7.7.49;
Uniprot:
M-CSA:
RHEA:22508 a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].([*:7]-[OH;+0:8].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[O;H0;+0:13]-[*:14])>>([*:7]-[O;H0;+0:8]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[O;H0;+0:2]-[*:1]).[*:14]-[OH;+0:13]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
The terminal nucleotidyltransferases of calf thymus nuclei.Gottesman ME, Canellakis ES1966 Oct 104288534
Studies on the incorporation of deoxyribonucleic acid.KRAKOW JS, COUTSOGEORGOPOULOS C, CANELLAKIS ES1962 May 1414459258
Biochemical studies of bacterial sporulation. II. Deoxy- ribonucleic acid polymerase in spores of Bacillus subtilis.Falaschi A, Kornberg A1966 Apr 104957767
RNA-dependent DNA polymerase in virions of Rous sarcoma virus.Temin HM, Mizutani S1970 Jun 274316301
RNA-dependent DNA polymerase in virions of RNA tumour viruses.Baltimore D1970 Jun 274316300
Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli.LEHMAN IR, BESSMAN MJ, SIMMS ES, KORNBERG A1958 Jul13563462