EC number:2.7.7.50
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.7 Nucleotidyltransferases |
| ID: | 2.7.7.50 |
|---|---|
| Description: | mRNA guanylyltransferase. |
| Alternative Name: |
mRNA capping enzyme. GTP--RNA guanylyltransferase. |
| Cath: | 3.20.100.10; 3.20.100.20; 3.30.1490.430; 3.30.470.140; 3.30.470.30; 4.10.87.10; 3.55.60.10; 3.90.1810.10; 3.90.190.10; 2.40.50.140; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.7.50 |
| BRENDA Enzyme Link: | BRENDA 2.7.7.50 |
| KEGG Enzyme Link: | KEGG2.7.7.50 |
| BioCyc Enzyme Link: | BioCyc 2.7.7.50 |
| ExPASy Enzyme Link: | ExPASy2.7.7.50 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.7.50 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.7.50 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.7.50 |
| IntEnz Enzyme Link: | IntEnz 2.7.7.50 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.7.50 |
| RHEA:54592 | a 5'-diphospho-(purine-ribonucleotide)-[mRNA] + GTP + H(+) = a 5'-(5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] + diphosphate |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]-[OH;+0:6].[H+;H0:7]>>[*:5]-[O;H0;+0:6]-[CH2;+0:2]-[*:1].[*:4]-[OH;+0:3] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. Large scale purification, subunit functions, and subcellular localization. | Itoh N, Yamada H, Kaziro Y, Mizumoto K | 1987 Feb 15 | 3029058 |
| An RNA 5'-triphosphatase related to the protein tyrosine phosphatases. | Takagi T, Moore CR, Diehn F, Buratowski S | 1997 Jun 13 | 9200605 |
| Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates. | Groner Y, Gilboa E, Aviv H | 1978 Mar 21 | 629955 |
| mRNA capping: biological functions and applications. | Ramanathan A, Robb GB, Chan SH | 2016 Sep 19 | 27317694 |
| Enzymology of RNA cap synthesis. | Ghosh A, Lima CD | 2010 Jul-Aug | 21956912 |
| Structural insights to how mammalian capping enzyme reads the CTD code. | Ghosh A, Shuman S, Lima CD | 2011 Jul 22 | 21683636 |
| Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions. | Martin SA, Moss B | 1975 Dec 25 | 1194287 |
| Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions. | Martin SA, Paoletti E, Moss B | 1975 Dec 25 | 1194286 |
| Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus. | Ensinger MJ, Martin SA, Paoletti E, Moss B | 1975 Jul | 1058472 |